ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate

Base Information

Chemical Name:ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate
CAS No.:1041612-02-5
Molecular Formula:C₃₁H₃₆F₃N₃O₈S
Molecular Weight:667.703
Hs Code.:

ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate

Synonyms:ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate

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Chemical Property of ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate

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Technology Process of ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate

There total 4 articles about ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1041611-84-0
3-[(R)-3-t-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)-butyryl]-thiazolidine-2-carboxylic acid

: 1041612-03-6
ethyl 6-aminomethyl-2,3-dihydrobenzo[1,4]dioxin-2-carboxylate hydrochloride

: 1041612-02-5
ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 1041611-84-0
3-[(R)-3-t-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)-butyryl]-thiazolidine-2-carboxylic acid

: 1041629-66-6
C₁₂H₁₅NO₄

: 1041612-02-5
ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2011.01.041

Reference yield:

: 1283679-05-9
C₂₁H₂₇F₃N₂O₅S

: 1041612-02-5
ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 12 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C

With water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.041