(R)-2,3,4,5-Tetrahydro-4-(phenylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile

Base Information

Chemical Name:(R)-2,3,4,5-Tetrahydro-4-(phenylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile
CAS No.:195985-69-4
Molecular Formula:C₂₃H₂₁N₃O₂S
Molecular Weight:403.505
Hs Code.:

Synonyms:(R)-2,3,4,5-Tetrahydro-4-(phenylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile

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Chemical Property of (R)-2,3,4,5-Tetrahydro-4-(phenylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile

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Technology Process of (R)-2,3,4,5-Tetrahydro-4-(phenylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile

There total 4 articles about (R)-2,3,4,5-Tetrahydro-4-(phenylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 195984-90-8
(R)-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile

: 195985-69-4
(R)-2,3,4,5-Tetrahydro-4-(phenylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 58h;
DOI:10.1021/jm000248z

Reference yield:

: 195984-33-9
(R)-7-bromo-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine

: 195985-69-4
(R)-2,3,4,5-Tetrahydro-4-(phenylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 1-methyl-2-pyrrolidinone / 3.5 h / 200 °C

2: DIEA / CH₂Cl₂ / 58 h / 20 °C

With 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Substitution / 2: Sulfonylation;
DOI:10.1021/jm000248z

Reference yield:

: 195984-32-8
(R)-7-bromo-2,3,4,5-tetrahydro-3-(phenylmethyl)-1H-1,4-benzodiazepine-2,5-dione

: 195985-69-4
(R)-2,3,4,5-Tetrahydro-4-(phenylsulfonyl)-3-(phenylmethyl)-1H-1,4-benzodiazepine-7-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / BH₃*THF / tetrahydrofuran / 18 h / Heating

2: 80 percent / 1-methyl-2-pyrrolidinone / 3.5 h / 200 °C

3: DIEA / CH₂Cl₂ / 58 h / 20 °C

With 1-methyl-pyrrolidin-2-one; borane-THF; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 1: Reduction / 2: Substitution / 3: Sulfonylation;
DOI:10.1021/jm000248z