9-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-chloro-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one

Base Information

Chemical Name:9-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-chloro-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one
CAS No.:1434515-75-9
Molecular Formula:C₂₆H₂₉ClO₂Si
Molecular Weight:437.054
Hs Code.:

Synonyms:9-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-chloro-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one

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Chemical Property of 9-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-chloro-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one

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Technology Process of 9-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-chloro-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one

There total 1 articles about 9-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-chloro-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1434515-71-5
(E)-1-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-(4-chlorophenyl)hept-6-en-1-yn-3-one

: 1434515-75-9
9-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-chloro-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one

Guidance literature:: In 1,2-dichloro-benzene; at 225 ℃; for 1h; Microwave irradiation;
DOI:10.1021/ol400292q

Reference yield: 52.0%

: 1434515-75-9
9-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-chloro-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one

: 124-40-3
dimethyl amine

: 1434515-80-6
9-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-(dimethylamino)-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one

Guidance literature:: With (SPhos) palladium(II) phenethylamine chloride; lithium hexamethyldisilazane; In tetrahydrofuran; at 85 ℃; for 3h; Sealed tube; Inert atmosphere;
DOI:10.1021/ol400292q

Reference yield:

: 1434515-75-9
9-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)-7-chloro-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one

: 1434515-84-0
7-(dimethylamino)-9-(4-(hydroxymethyl)phenyl)-2,3-dihydro-1H-cyclopenta[b]naphthalen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: (SPhos) palladium(II) phenethylamine chloride; lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 85 °C / Sealed tube; Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With (SPhos) palladium(II) phenethylamine chloride; tetrabutyl ammonium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; 1: |Buchwald-Hartwig Coupling;
DOI:10.1021/ol400292q