N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonyl-3-methyl-indo-2-lyl)methyl]-α-carboethoxy-α-diazoacetamide

Base Information

Chemical Name:N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonyl-3-methyl-indo-2-lyl)methyl]-α-carboethoxy-α-diazoacetamide
CAS No.:1083078-00-5
Molecular Formula:C₂₈H₃₈N₄O₅SSi₂
Molecular Weight:598.871
Hs Code.:

Synonyms:N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonyl-3-methyl-indo-2-lyl)methyl]-α-carboethoxy-α-diazoacetamide

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Chemical Property of N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonyl-3-methyl-indo-2-lyl)methyl]-α-carboethoxy-α-diazoacetamide

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Technology Process of N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonyl-3-methyl-indo-2-lyl)methyl]-α-carboethoxy-α-diazoacetamide

There total 3 articles about N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonyl-3-methyl-indo-2-lyl)methyl]-α-carboethoxy-α-diazoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 57072-87-4
chlorocarbonyl-diazo-acetic acid ethyl ester

: 1-phenylsulfonyl-2,3-dimethylindole

: 1083078-00-5
N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonyl-3-methyl-indo-2-lyl)methyl]-α-carboethoxy-α-diazoacetamide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 1.33333h; Inert atmosphere;
DOI:10.1039/c2ob25103e

Reference yield:

: 164261-56-7
1-(Phenylsulfonyl)-3-methyl-2-(bromomethyl)indole

: 1083078-00-5
N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonyl-3-methyl-indo-2-lyl)methyl]-α-carboethoxy-α-diazoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; sodium iodide / N,N-dimethyl-formamide / 3.5 h / 65 - 70 °C / Inert atmosphere

2: 2,6-dimethylpyridine / dichloromethane / 1.33 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium carbonate; sodium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25103e

Reference yield:

: 116325-48-5
N-benzenesulfonyl-2,3-dimethyl-1H-indole

: 1083078-00-5
N-[bis(trimethylsilyl)methyl]-N-[(1-phenylsulfonyl-3-methyl-indo-2-lyl)methyl]-α-carboethoxy-α-diazoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

2: sodium carbonate; sodium iodide / N,N-dimethyl-formamide / 3.5 h / 65 - 70 °C / Inert atmosphere

3: 2,6-dimethylpyridine / dichloromethane / 1.33 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; N-Bromosuccinimide; sodium carbonate; sodium iodide; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25103e