(4S,5R)-4-(fluoromethyl)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole

Base Information

Chemical Name:(4S,5R)-4-(fluoromethyl)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole
CAS No.:126429-04-7
Molecular Formula:C₁₈H₁₈FNO₄S
Molecular Weight:363.41
Hs Code.:

Synonyms:(4S,5R)-4-(fluoromethyl)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole

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Chemical Property of (4S,5R)-4-(fluoromethyl)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole

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Technology Process of (4S,5R)-4-(fluoromethyl)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole

There total 5 articles about (4S,5R)-4-(fluoromethyl)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1373543-45-3
{(4R,5R)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazol-4-yl}methanol

: 126429-04-7
(4S,5R)-4-(fluoromethyl)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole

Guidance literature:: With hexafluoropropene-diethylamine adduct; In dichloromethane; at 100 ℃; for 3h; Inert atmosphere; sealed tube;
DOI:10.1055/s-0031-1289706

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 126429-04-7
(4S,5R)-4-(fluoromethyl)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / ethanol; dichloromethane / 10 h / 0 - 4 °C / Inert atmosphere

2: thionyl chloride / chloroform / 0.5 h / 45 °C / Inert atmosphere

3: sodium tetrahydroborate; calcium chloride / ethanol / 5 h / 0 - 20 °C / Inert atmosphere

4: hexafluoropropene-diethylamine adduct / dichloromethane / 3 h / 100 °C / Inert atmosphere; sealed tube

With sodium tetrahydroborate; thionyl chloride; hexafluoropropene-diethylamine adduct; triethylamine; calcium chloride; In ethanol; dichloromethane; chloroform;
DOI:10.1055/s-0031-1289706

Reference yield:

: C₁₂H₁₇NO₅S

: 126429-04-7
(4S,5R)-4-(fluoromethyl)-2-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]-4,5-dihydro-1,3-oxazole

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / ethanol; dichloromethane / 10 h / 0 - 4 °C / Inert atmosphere

2: thionyl chloride / chloroform / 0.5 h / 45 °C / Inert atmosphere

3: sodium tetrahydroborate; calcium chloride / ethanol / 5 h / 0 - 20 °C / Inert atmosphere

4: hexafluoropropene-diethylamine adduct / dichloromethane / 3 h / 100 °C / Inert atmosphere; sealed tube

With sodium tetrahydroborate; thionyl chloride; hexafluoropropene-diethylamine adduct; triethylamine; calcium chloride; In ethanol; dichloromethane; chloroform;
DOI:10.1055/s-0031-1289706