6-methyl-9-{(5E)-5,6,7-trideoxy-7-[6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxamido]-β-D-ribo-hept-5-enofuranosyl}-purine

Base Information

Chemical Name:6-methyl-9-{(5E)-5,6,7-trideoxy-7-[6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxamido]-β-D-ribo-hept-5-enofuranosyl}-purine
CAS No.:1312944-68-5
Molecular Formula:C₄₁H₃₆FN₅O₈
Molecular Weight:745.764
Hs Code.:

Synonyms:6-methyl-9-{(5E)-5,6,7-trideoxy-7-[6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxamido]-β-D-ribo-hept-5-enofuranosyl}-purine

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Chemical Property of 6-methyl-9-{(5E)-5,6,7-trideoxy-7-[6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxamido]-β-D-ribo-hept-5-enofuranosyl}-purine

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Technology Process of 6-methyl-9-{(5E)-5,6,7-trideoxy-7-[6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxamido]-β-D-ribo-hept-5-enofuranosyl}-purine

There total 9 articles about 6-methyl-9-{(5E)-5,6,7-trideoxy-7-[6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxamido]-β-D-ribo-hept-5-enofuranosyl}-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1204745-05-0
6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid

: C₁₇H₂₁N₅O₅

: 1312944-68-5
6-methyl-9-{(5E)-5,6,7-trideoxy-7-[6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxamido]-β-D-ribo-hept-5-enofuranosyl}-purine

Guidance literature:: 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h; Inert atmosphere;

C₁₇H₂₁N₅O₅; In N,N-dimethyl-formamide; at 0 ℃; for 5h; Inert atmosphere;
DOI:10.1002/chem.201003648

Reference yield:

: 6-bromo-2,2-bis-(4-methoxy-phenyl)-benzo[1,3]dioxole-4-carboxylic acid methyl ester

: 1312944-68-5
6-methyl-9-{(5E)-5,6,7-trideoxy-7-[6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxamido]-β-D-ribo-hept-5-enofuranosyl}-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 3 h / 100 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / 70 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 5 h / 0 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; water; N,N-dimethyl-formamide; toluene; 1.1: Suzuki coupling;
DOI:10.1002/chem.201003648

Reference yield:

: 1204745-07-2
methyl 6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxylate

: 1312944-68-5
6-methyl-9-{(5E)-5,6,7-trideoxy-7-[6-(4-fluorophenyl)-2,2-bis(4-methoxyphenyl)-1,3-benzodioxole-4-carboxamido]-β-D-ribo-hept-5-enofuranosyl}-purine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / 70 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 5 h / 0 °C / Inert atmosphere

With lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;
DOI:10.1002/chem.201003648