2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyrido[2,3-d]pyrimidine

Base Information

Chemical Name:2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyrido[2,3-d]pyrimidine
CAS No.:1067649-53-9
Molecular Formula:C₂₉H₂₂Cl₂FN₃
Molecular Weight:502.418
Hs Code.:

Synonyms:2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyrido[2,3-d]pyrimidine

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Chemical Property of 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyrido[2,3-d]pyrimidine

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Technology Process of 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyrido[2,3-d]pyrimidine

There total 7 articles about 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyrido[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1065267-61-9
2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine

: 1765-93-1
4-fluoroboronic acid

: 1067649-53-9
2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyrido[2,3-d]pyrimidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 120 ℃; Microwave irradiation;
DOI:10.1016/j.bmcl.2009.03.005

Reference yield:

: 7504-29-2
1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone

: 1067649-53-9
2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1: N,N-dimethyl-formamide / 16 h / 75 °C

2: sodium hydride / methanol; N,N-dimethyl-formamide; mineral oil / 2.5 h / 95 °C

3: trichlorophosphate / 17 h / 100 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.42 h / 130 °C / Sealed microwave tube

5: methanesulfonic acid; water / 113 °C

6: trichlorophosphate / toluene / 1 h / 108 °C

7: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 120 °C / Inert atmosphere; Microwave irradiation

With methanesulfonic acid; water; sodium hydride; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 611220-89-4
2-chloro-6-(2-chlorophenyl)-5-(4-chlorophenyl)-pyridine-3-carbonitrile

: 1067649-53-9
2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)-4-(4-fluorophenyl)pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.42 h / 130 °C / Sealed microwave tube

2: methanesulfonic acid; water / 113 °C

3: trichlorophosphate / toluene / 1 h / 108 °C

4: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.25 h / 120 °C / Inert atmosphere; Microwave irradiation

With methanesulfonic acid; water; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;