2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine

Base Information

Chemical Name:2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine
CAS No.:1065267-61-9
Molecular Formula:C₂₃H₁₈Cl₃N₃
Molecular Weight:442.775
Hs Code.:

Synonyms:2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine

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Chemical Property of 2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine

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Technology Process of 2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine

There total 8 articles about 2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1065267-60-8
C₂₃H₁₉Cl₂N₃O

: 1065267-61-9
2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine

Guidance literature:: With trichlorophosphate; In toluene; at 108 ℃;
DOI:10.1016/j.bmcl.2009.03.005

Reference yield:

: 1065267-60-8
2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one

: 1065267-61-9
2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine

Guidance literature:: With trichlorophosphate; In toluene; at 108 ℃; for 1h;

Reference yield:

: 7504-29-2
1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone

: 1065267-61-9
2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethyl-formamide / 16 h / 75 °C

2: sodium hydride / methanol; hexane; N,N-dimethyl-formamide; mineral oil / 2.5 h / 95 °C

3: trichlorophosphate / 17 h / 100 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.42 h / 130 °C / Microwave irradiation; Sealed tube

5: methanesulfonic acid; water / 113 °C

6: trichlorophosphate / toluene / 1 h / 108 °C

With methanesulfonic acid; water; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In methanol; hexane; N,N-dimethyl-formamide; toluene; mineral oil;