8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

Base Information

Chemical Name:8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline
CAS No.:1417411-73-4
Molecular Formula:C₁₆H₉BrClN₅O₂
Molecular Weight:418.637
Hs Code.:

Synonyms:8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

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Chemical Property of 8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

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Technology Process of 8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

There total 4 articles about 8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 600-22-6
pyruvic acid methyl ester

: 5344-49-0
2-chloro-6-nitrobenzoic acid

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1417411-73-4
8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

: 1417411-74-5
8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

Guidance literature:: pyruvic acid methyl ester; 4-Bromo-benzene-1,2-diamine; In toluene; for 3h; Dean-Stark; Reflux;

With trichlorophosphate; at 120 ℃; for 2h;

2-chloro-6-nitrobenzoic acid;

Reference yield: 13.7%

: 1417411-71-2
C₁₆H₁₁BrClN₅O₃

: 1417411-72-3
C₁₆H₁₁BrClN₅O₃

: 1417411-73-4
8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

: 1417411-74-5
8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

Guidance literature:: With trichlorophosphate; In 1,2-dichloro-ethane; at 160 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 1392413-56-7
6-bromo-3-chloro-2-methylquinoxaline

: 1417411-73-4
8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / methanol; water / 0.5 h / 50 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.25 h / 20 °C

2.2: 0.25 h / 0 - 20 °C

3.1: trichlorophosphate / 1,2-dichloro-ethane / 0.17 h / 160 °C / Microwave irradiation

With oxalyl dichloride; hydrazine hydrate; N,N-dimethyl-formamide; trichlorophosphate; In methanol; dichloromethane; water; 1,2-dichloro-ethane;