3,3-Dimethoxy-2-(hydroxymethylene)propionitrile sodium salt

Base Information

• Chemical Name: 3,3-Dimethoxy-2-(hydroxymethylene)propionitrile sodium salt
• CAS No.: 105161-33-9
• Molecular Formula: C6H9 N O3 . Na
• Molecular Weight: 165.124
• Mol file: 105161-33-9.mol

Synonyms:2-Propenenitrile,2-(dimethoxymethyl)-3-hydroxy-, sodium salt (9CI); 2-Hydroxymethylene-3,3-dimethoxypropanenitrilesodium salt

Chemical Property of 3,3-Dimethoxy-2-(hydroxymethylene)propionitrile sodium salt

Chemical Property:

• PSA: 59.32000
• LogP: 0.03578

Purity/Quality:

98% Min ^*data from raw suppliers

2-Hydroxymethylene-3,3-dimethoxypropanenitrilesodiumsalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Hydroxymethylene-3,3-dimethoxypropanenitrile sodium salt is a useful reactant and reagent in organic reactions and synthesis.

Technology Process of 3,3-Dimethoxy-2-(hydroxymethylene)propionitrile sodium salt

There total 7 articles about 3,3-Dimethoxy-2-(hydroxymethylene)propionitrile sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Methyl formate (107-31-3) + 3,3-dimethoxypropionitrile (57597-62-3) → 3,3-dimethyloxy-2-formylpropionitrile sodium salt (105161-33-9)

Guidance literature:

With sodium hydride; In diethyl ether; at 20 ℃; for 48h;

DOI:10.1021/jm701344b

Reference yield: 70.0%

3,3-dimethoxypropionitrile (57597-62-3) + formic acid ethyl ester (109-94-4) → sodium (E)-2-cyano-3,3-dimethoxy-prop-1-en-1-olate (105161-33-9)

Guidance literature:

With sodium hydride; In diethyl ether; at 20 ℃; for 48h;

Reference yield: 46.3%

Methyl formate (107-31-3) + 3,3-dimethoxypropionitrile (57597-62-3) → sodium (E)-2-cyano-3,3-dimethoxy-prop-1-en-1-olate (105161-33-9)

Guidance literature:

upstream raw materials:

Methyl formate

3,3-dimethoxypropionitrile

formic acid ethyl ester

3-methoxy-2-propenenitrile

Downstream raw materials:

thieno[3,2-b]pyridine-6-carbonitrile

(Z)-2-Formyl-3-(3-methoxy-phenylamino)-acrylonitrile

2-(pyridin-3-yl)pyrimidine-5-carbonitrile

2-phenylpyrimidine-5-carbonitrile