4-Thiazolecarboxylicacid,4,5-dihydro-,methylester,(4R)-(9CI)

Base Information

Chemical Name:4-Thiazolecarboxylicacid,4,5-dihydro-,methylester,(4R)-(9CI)
CAS No.:105118-41-0
Molecular Formula:C5H7 N O2 S
Molecular Weight:145.182
Hs Code.:
Mol file:105118-41-0.mol

Synonyms:4-Thiazolecarboxylicacid, 4,5-dihydro-, methyl ester, (R)-

Suppliers and Price of 4-Thiazolecarboxylicacid,4,5-dihydro-,methylester,(4R)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Thiazolecarboxylicacid,4,5-dihydro-,methylester,(4R)-(9CI)

Chemical Property:

PSA：63.96000
LogP:-0.26130

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Thiazolecarboxylicacid,4,5-dihydro-,methylester,(4R)-(9CI)

There total 2 articles about 4-Thiazolecarboxylicacid,4,5-dihydro-,methylester,(4R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 64-18-6
formic acid

: 1393377-75-7
dimethyl (2R,2'R)-3,3'-disulfanediylbis(2-azidopropanoate)

: 105118-41-0
4,5-dihydrothiazole-4-carboxylic acid methyl ester

Guidance literature:: formic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

dimethyl (2R,2'R)-3,3'-disulfanediylbis(2-azidopropanoate); With tributylphosphine; In dichloromethane; at 20 ℃; for 1h; Darkness;

With triphenylphosphine; In dichloromethane; for 5h; Reflux;
DOI:10.1021/jo301030k

Reference yield:

: 18598-63-5
L-cysteine methyl ester hydrochloride

: 122-51-0
orthoformic acid triethyl ester

: 105118-41-0
4,5-dihydrothiazole-4-carboxylic acid methyl ester

: 4,5-dihydrothiazole-4-carboxylic acid methyl ester

Guidance literature:: With 4 A molecular sieve; TEA; toluene-4-sulfonic acid; In 1,2-dichloro-ethane; for 20h; Heating;
DOI:10.1039/b210551a

Reference yield: 98.0%

: 106-96-7
propargyl bromide

: 105118-41-0
4,5-dihydrothiazole-4-carboxylic acid methyl ester

: (+/-)-4,5-dihydrothiazole-4-carboxylic acid prop-2-ynyl ester

Guidance literature:: 4,5-dihydrothiazole-4-carboxylic acid methyl ester; With cesium hydroxide; In methanol; at 20 ℃;

propargyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃; Further stages.;
DOI:10.1039/b210551a