N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<2-hydroxy-3-methoxy-3-oxo-1-(phenylmethyl)propyl>-L-prolinamide

Base Information

Chemical Name:N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<2-hydroxy-3-methoxy-3-oxo-1-(phenylmethyl)propyl>-L-prolinamide
CAS No.:123206-33-7
Molecular Formula:C₂₇H₃₈N₄O₉
Molecular Weight:562.62
Hs Code.:

Synonyms:N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<2-hydroxy-3-methoxy-3-oxo-1-(phenylmethyl)propyl>-L-prolinamide

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Chemical Property of N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<2-hydroxy-3-methoxy-3-oxo-1-(phenylmethyl)propyl>-L-prolinamide

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Technology Process of N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<2-hydroxy-3-methoxy-3-oxo-1-(phenylmethyl)propyl>-L-prolinamide

There total 5 articles about N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<2-hydroxy-3-methoxy-3-oxo-1-(phenylmethyl)propyl>-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103127-53-3
N-tert-butyloxycarbonyl-2-amino-3-phenylpropionaldehyde

: 123206-33-7
N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<2-hydroxy-3-methoxy-3-oxo-1-(phenylmethyl)propyl>-L-prolinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaHSO₃ / 1.) H₂O, 4 deg C, overnight, 2.) EtOAc, RT, 4.5 h

2: conc. aq. HCl / dioxane / Heating

3: HCl / 0 - 20 °C

4: N-methylmorpholine / acetonitrile; CHCl₃ / 1.) -20 deg C, 4 h, 2.) RT, overnight

With 4-methyl-morpholine; hydrogenchloride; sodium hydrogensulfite; In 1,4-dioxane; chloroform; acetonitrile;
DOI:10.1021/jm00163a063

Reference yield:

: 62084-21-3
(2RS,3RS)-3-amino-2-hydroxy-4-phenylbutanoic acid

: 123206-33-7
N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<2-hydroxy-3-methoxy-3-oxo-1-(phenylmethyl)propyl>-L-prolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / 0 - 20 °C

2: N-methylmorpholine / acetonitrile; CHCl₃ / 1.) -20 deg C, 4 h, 2.) RT, overnight

With 4-methyl-morpholine; hydrogenchloride; In chloroform; acetonitrile;
DOI:10.1021/jm00163a063

Reference yield:

: (1-Benzyl-2-cyano-2-oxo-ethyl)-carbamic acid tert-butyl ester

: 123206-33-7
N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<2-hydroxy-3-methoxy-3-oxo-1-(phenylmethyl)propyl>-L-prolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: conc. aq. HCl / dioxane / Heating

2: HCl / 0 - 20 °C

3: N-methylmorpholine / acetonitrile; CHCl₃ / 1.) -20 deg C, 4 h, 2.) RT, overnight

With 4-methyl-morpholine; hydrogenchloride; In 1,4-dioxane; chloroform; acetonitrile;
DOI:10.1021/jm00163a063