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TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE is a versatile chemical compound that features a tert-butyl group, a benzyl group, and a carbamate functional group. It is widely recognized for its role as a protecting group in organic synthesis, where it temporarily shields the reactivity of certain functional groups such as amines. TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE can be conveniently added and removed under specific conditions, providing chemists with the ability to control reaction processes and selectively modify the desired functional groups.

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  • 103127-53-3 Structure
  • Basic information

    1. Product Name: TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE
    2. Synonyms: TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE;tert-butyl 1-oxo-3-phenylpropan-2-ylcarbaMate(raceMic);tert-butyl 1-oxo-3-phenylpropan-2-ylcarbamate
    3. CAS NO:103127-53-3
    4. Molecular Formula: C14H19NO3
    5. Molecular Weight: 249.308
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 103127-53-3.mol
  • Chemical Properties

    1. Melting Point: 68-70°C
    2. Boiling Point: 367°Cat760mmHg
    3. Flash Point: 175.8°C
    4. Appearance: /
    5. Density: 1.077g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE(CAS DataBase Reference)
    10. NIST Chemistry Reference: TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE(103127-53-3)
    11. EPA Substance Registry System: TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE(103127-53-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 103127-53-3(Hazardous Substances Data)

103127-53-3 Usage

Uses

Used in Organic Synthesis:
TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE is used as a protecting group for amines during chemical reactions, allowing chemists to control the reaction process and selectively modify the desired functional groups. Its easy addition and removal under specific conditions make it a valuable tool in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE is utilized for the synthesis of complex molecules. Its role as a protecting group aids in the controlled formation of pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE also finds application in the agrochemical industry, where it serves as a building block for the production of various compounds. Its use in the synthesis of agrochemicals helps in the development of effective pesticides, herbicides, and other agricultural chemicals.
Safety Precautions:
It is crucial to handle and use TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE with proper safety measures, as it can pose hazards if not managed correctly. Adhering to safety protocols ensures the protection of both the environment and the individuals involved in its production and application.

Check Digit Verification of cas no

The CAS Registry Mumber 103127-53-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,1,2 and 7 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 103127-53:
(8*1)+(7*0)+(6*3)+(5*1)+(4*2)+(3*7)+(2*5)+(1*3)=73
73 % 10 = 3
So 103127-53-3 is a valid CAS Registry Number.

103127-53-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Methyl-2-propanyl (1-oxo-3-phenyl-2-propanyl)carbamate

1.2 Other means of identification

Product number -
Other names N-tert-butoxycarbonylphenylalaninal

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:103127-53-3 SDS

103127-53-3Relevant articles and documents

Fluorinated Olefinic Lactams: The Case of Amino Acids - Preparation and Mechanistic Studies

Bartoszak-Adamska, El?bieta,Go?dyn, Mateusz,Koroniak, Henryk,Koroniak-Szejn, Katarzyna,Salamon-Krokosz, Katarzyna,Siod?a, Tomasz

, (2022/03/17)

Herein, we report the synthesis of analogues of amino acids with a monofluorovinyl moiety. Interestingly, we have found that cyclization of the obtained products proceeds easily in all cases. The cyclization process has not previously been observed at this reaction stage, and such fluorinated lactams derived from phenylalanine, valine, alanine have not been described before.

METHODS OF TREATING LIVER FIBROSIS USING CALPAIN INHIBITORS

-

Paragraph 0342, (2020/01/24)

Disclosed herein are methods of treating liver fibrosis by administering calpain inhibitors to subjects in need thereof.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

-

Paragraph 0398, (2019/10/23)

Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by contacting them with CAPN1, CAPN2, and/or CAPN9 enzymes residing inside a subject. The compounds and composition can also be administered to a subject in order to treat a fibrotic disease or a secondary disease state or condition of a fibrotic disease.

Membrane-active antimicrobial poly(amino-modified alkyl) β-cyclodextrins synthesized: Via click reactions

Yamamura, Hatsuo,Nonaka, Miho,Okuno, Shingo,Mitsuhashi, Ryogo,Kato, Hisato,Katsu, Takashi,Masuda, Kazufumi,Tanimoto, Koichi,Tomita, Haruyoshi,Miyagawa, Atsushi

, p. 509 - 518 (2018/03/26)

The emergence of drug-resistant bacteria has led to the high demand for new antibiotics. In this report, we investigated membrane-active antimicrobial β-cyclodextrins. These contain seven amino-modified alkyl groups on a molecule, which act as functional

A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H

Ivkovic, Jakov,Lembacher-Fadum, Christian,Breinbauer, Rolf

supporting information, p. 10456 - 10460 (2015/11/10)

N-Protected amino acids can be easily converted into chiral α-amino aldehydes in a one-pot reaction by activation with CDI followed by reduction with DIBAL-H. This method delivers Boc-, Cbz- and Fmoc-protected amino aldehydes from proteinogenic amino acids in very good isolated yields and complete stereointegrity.

Synthesis of proline analogues as potent and selective cathepsin S inhibitors

Kim, Mira,Jeon, Jiyoung,Song, Jiyeon,Suh, Kwee Hyun,Kim, Young Hoon,Min, Kyung Hoon,Lee, Kwang-Ok

, p. 3140 - 3144 (2013/06/26)

Cathepsin S is a potential target of autoimmune disease. A series of proline derived compounds were synthesized and evaluated as cathepsin S inhibitors. We discovered potent cathepsin S inhibitors through structure-activity relationship studies of proline analogues. In particular, compound 19-(S) showed promising in vitro/vivo pharmacological activities and properties as a selective cathepsin S inhibitor.

Synthesis and cytotoxicity evaluation of diastereoisomers and N-terminal analogues of tubulysin-U

Shankar, P. Sreejith,Bigotti, Serena,Lazzari, Paolo,Manca, Ilaria,Spiga, Marco,Sani, Monica,Zanda, Matteo

, p. 6137 - 6141 (2013/10/22)

Tubulysins are potent anti-mitotic natural compounds and a scalable and efficient synthetic route for generation of its analogues has been developed and extended to the synthesis of diastereoisomers and N-terminal analogues of tubulysin-U. Structure-activ

HETEROCYCLIC AMIDE COMPOUNDS AND PHARMACEUTICAL USE OF THE SAME

-

, (2008/06/13)

Heterocyclic amide compounds of the formula (I) STR1 wherein each symbol is as defined in the specification, pharmacologically acceptable salts thereof, pharmaceutical compositions thereof and pharmaceutical use thereof. The heterocyclic amide compounds and pharmacologically acceptable salts thereof of the present invention have superior inhibitory activity against chymase groups in mammals inclusive of human, and can be administered orally or parenterally. Therefore, they are useful as chymase inhibitors and can be effective for the prophylaxis and treatment of various diseases caused by chymase, such as those caused by angiotensin II.

Synthesis and Stereoselective Reactions of 2-(Pyrrol-1-yl)alkanals and 2-(pyrrol-1-yl)alkan-1-ones

Kashima, Choji,Maruyama, Tatsuya,Fujioka, Yoko,Harada, Kazuo

, p. 1041 - 1046 (2007/10/02)

2-(2,5-Dimethylpyrrol-1-yl)alkanals, 2-(pyrrol-1-yl)alkanals, and 2-(2,5-dimethylpyrrol-1-yl)alkan-1-ones were prepared.The reactions of these compounds with Grignard and hydride reagents proceeded stereoselectively to give the corresponding 2-(pyrrol-1-yl)alcohols, which were converted into 2-aminoalcohols, such as norephedrine and ephedrine, by cleavage of the pyrrole ring.

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