103127-53-3

Basic information

• Product Name: TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE
• Synonyms: TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE;tert-butyl 1-oxo-3-phenylpropan-2-ylcarbaMate(raceMic);tert-butyl 1-oxo-3-phenylpropan-2-ylcarbamate
• CAS NO: 103127-53-3
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.308
• Mol File: 103127-53-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 68-70°C
• Boiling Point: 367°Cat760mmHg
• Flash Point: 175.8°C
• Appearance: /
• Density: 1.077g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE(103127-53-3)
• EPA Substance Registry System: TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE(103127-53-3)

Safety Data

• Hazardous Substances Data: 103127-53-3(Hazardous Substances Data)

Usage

General Description

Tert-butyl (1-benzyl-2-oxoethyl)carbamate is a chemical compound that contains a tert-butyl group, a benzyl group, and a carbamate functional group. It is commonly used as a protecting group in organic synthesis to temporarily block the reactivity of certain functional groups, such as amines, during a chemical reaction. TERT-BUTYL (1-BENZYL-2-OXOETHYL)CARBAMATE can be easily added and removed under specific conditions, allowing chemists to control the reaction process and selectively modify the desired functional groups. Tert-butyl (1-benzyl-2-oxoethyl)carbamate is commonly used in pharmaceutical and agrochemical industries for the synthesis of complex molecules and as a building block for the production of various compounds. It is important to handle and use this chemical with proper safety precautions, as it can be hazardous if not handled correctly.

Upstream product

• 79-37-8 oxalyl dichloride 
• 145149-48-0 tert-butyl 1-hydroxy-3-phenylpropan-2-ylcarbamate 
• 77-92-9 citric acid 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 63-91-2 L-phenylalanine 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 4530-18-1 2-(tert-butoxycarbonylamino)-3-phenylpropionic acid 
• 1224936-68-8 N-(tert-butoxycarbonyl)-phenylalanylimidazole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1795-98-8 rac-phenylalaninol 
• 72155-45-4 Boc-L-phenylalaninal 

Relevant articles and documents

Fluorinated Olefinic Lactams: The Case of Amino Acids - Preparation and Mechanistic Studies

Herein, we report the synthesis of analogues of amino acids with a monofluorovinyl moiety. Interestingly, we have found that cyclization of the obtained products proceeds easily in all cases. The cyclization process has not previously been observed at this reaction stage, and such fluorinated lactams derived from phenylalanine, valine, alanine have not been described before.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by contacting them with CAPN1, CAPN2, and/or CAPN9 enzymes residing inside a subject. The compounds and composition can also be administered to a subject in order to treat a fibrotic disease or a secondary disease state or condition of a fibrotic disease.

A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H

N-Protected amino acids can be easily converted into chiral α-amino aldehydes in a one-pot reaction by activation with CDI followed by reduction with DIBAL-H. This method delivers Boc-, Cbz- and Fmoc-protected amino aldehydes from proteinogenic amino acids in very good isolated yields and complete stereointegrity.