N-(2-(((tert-butyl)amino)methyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

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Chemical Name:N-(2-(((tert-butyl)amino)methyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide
CAS No.:1373758-68-9
Molecular Formula:C₂₁H₂₂BrCl₂N₅O
Molecular Weight:511.249
Hs Code.:

Synonyms:N-(2-(((tert-butyl)amino)methyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

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Chemical Property of N-(2-(((tert-butyl)amino)methyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

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Technology Process of N-(2-(((tert-butyl)amino)methyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

There total 4 articles about N-(2-(((tert-butyl)amino)methyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

: 1373758-65-6
3-bromo-N-(4-chloro-2-formyl-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

: 75-64-9
tert-butylamine

: 1373758-68-9
N-(2-(((tert-butyl)amino)methyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: 3-bromo-N-(4-chloro-2-formyl-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide; tert-butylamine; In ethanol; at 20 ℃; for 2h;

With sodium tetrahydroborate; In methanol; for 2h;
DOI:10.1002/cjoc.201180295

Reference yield:

: 775331-65-2
(2-amino-5-chloro-3-methylphenyl)methanol

: 1373758-68-9
N-(2-(((tert-butyl)amino)methyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: manganese(IV) oxide / dichloromethane / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2.2: 2 h / 20 °C

3.1: ethanol / 2 h / 20 °C

3.2: 2 h

With manganese(IV) oxide; oxalyl dichloride; N,N-dimethyl-formamide; In ethanol; dichloromethane;
DOI:10.1002/cjoc.201180295

Reference yield:

: 20776-67-4
2-amino-5-chloro-3-methylbenzoic acid

: 1373758-68-9
N-(2-(((tert-butyl)amino)methyl)-4-chloro-6-methylphenyl)-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3.2: 2 h / 20 °C

4.1: ethanol / 2 h / 20 °C

4.2: 2 h

With manganese(IV) oxide; lithium aluminium tetrahydride; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/cjoc.201180295