Methyl 2-(2-aminobenzamido)-5-chlorobenzoate

Base Information

Chemical Name:Methyl 2-(2-aminobenzamido)-5-chlorobenzoate
CAS No.:59187-55-2
Molecular Formula:C₁₅H₁₃ClN₂O₃
Molecular Weight:304.733
Hs Code.:
DSSTox Substance ID:DTXSID901231734

Synonyms:59187-55-2;methyl 2-(2-aminobenzamido)-5-chlorobenzoate;SCHEMBL896770;DTXSID901231734;AKOS010463087;EN300-27731139;Methyl 2-[(2-aminobenzoyl)amino]-5-chlorobenzoate

Suppliers and Price of Methyl 2-(2-aminobenzamido)-5-chlorobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 2-(2-aminobenzamido)-5-chlorobenzoate

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:304.0614700
Heavy Atom Count:21
Complexity:391

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=C(C=CC(=C1)Cl)NC(=O)C2=CC=CC=C2N

Technology Process of Methyl 2-(2-aminobenzamido)-5-chlorobenzoate

There total 7 articles about Methyl 2-(2-aminobenzamido)-5-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: C₁₅H₁₁ClN₂O₅

: 59187-55-2
N-(4-chloro-2-methoxycarbonylphenyl)-(2-amino)phenylcarboxamide

Guidance literature:: With methanol; sodium tetrahydroborate; nickel(II) nitrate hexahydrate; at 0 ℃; for 2h; Inert atmosphere;

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 59187-55-2
N-(4-chloro-2-methoxycarbonylphenyl)-(2-amino)phenylcarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

2: iron(III) chloride; pyrographite; hydrazine hydrate / methanol / 3 h / 65 °C / Inert atmosphere; Reflux

With pyridine; iron(III) chloride; pyrographite; hydrazine hydrate; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm201636v

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 59187-55-2
N-(4-chloro-2-methoxycarbonylphenyl)-(2-amino)phenylcarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / 1,2-dichloro-ethane / 0.67 h / 20 °C / Inert atmosphere

2: pyridine / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

3: iron(III) chloride; pyrographite; hydrazine hydrate / methanol / 3 h / 65 °C / Inert atmosphere; Reflux

With pyridine; iron(III) chloride; oxalyl dichloride; pyrographite; hydrazine hydrate; N,N-dimethyl-formamide; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm201636v