(S)-methyl-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

Base Information

Chemical Name:(S)-methyl-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate
CAS No.:178306-45-1
Molecular Formula:C₂₃H₂₄N₂O₆
Molecular Weight:424.453
Hs Code.:

Synonyms:(S)-methyl-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

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Technology Process of (S)-methyl-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

There total 4 articles about (S)-methyl-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 113583-35-0
4,6-dimethoxypyrimidin-2-yl methyl sulfone

: 178306-47-3
2-hydroxy-3-methoxy-3,3-diphenylpropionicacid methyl ester

: 178306-45-1
(S)-methyl-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

Guidance literature:: 2-hydroxy-3-methoxy-3,3-diphenylpropionicacid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; for 1h;

4,6-dimethoxypyrimidin-2-yl methyl sulfone; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 298-06-6
O,O-Diethyl hydrogen phosphorodithioate

: 113583-35-0
4,6-dimethoxypyrimidin-2-yl methyl sulfone

: 178306-47-3
2-hydroxy-3-methoxy-3,3-diphenylpropionicacid methyl ester

: 178306-45-1
(S)-methyl-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

Guidance literature:: With potassium carbonate; In n-heptane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 119-61-9
benzophenone

: 178306-45-1
(S)-methyl-2-(4,6-dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / NaOMe / tetrahydrofuran / 0.5 h / 0 °C

2: 98 percent / BF₃*Et₂O / 0.33 h / 0 °C

3: 1.) K₂CO₃ / 1.) DMF, 0.5 h, 2.) DMF, 90 deg C, 3 h

With boron trifluoride diethyl etherate; sodium methylate; potassium carbonate; In tetrahydrofuran;
DOI:10.1021/jm960274q