Technology Process of 4-bromo-2-nitro-6-tetrahydrofuran-2-yl-aniline
There total 6 articles about 4-bromo-2-nitro-6-tetrahydrofuran-2-yl-aniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
1,4-dioxane; water;
for 48h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / palladium diacetate; (R)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine ethanol adduct / 1,4-dioxane / 105 °C / Inert atmosphere; Sealed tube
1.2: 20 °C / 1551.49 Torr
2.1: N-Bromosuccinimide / acetonitrile; tert-butyl methyl ether / 0.5 h / 2 - 8 °C
3.1: ammonium nitrate / 2-methyltetrahydrofuran / 1.42 h / 2 - 40 °C
4.1: sodium hydroxide; water / 1,4-dioxane / 48 h / Reflux
With
N-Bromosuccinimide; ammonium nitrate; water; potassium carbonate; sodium hydroxide;
(R)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine ethanol adduct; palladium diacetate;
In
2-methyltetrahydrofuran; 1,4-dioxane; tert-butyl methyl ether; acetonitrile;
1.1: Heck coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-Bromosuccinimide; sodium thiosulfate / tert-butyl methyl ether
2: trifluoroacetic anhydride; ammonium nitrate
3: NaOH / 1,4-dioxane
With
N-Bromosuccinimide; NaOH; ammonium nitrate; sodium thiosulfate; trifluoroacetic anhydride;
In
1,4-dioxane; tert-butyl methyl ether;
