N-(4-bromo-2-nitro-6-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

Base Information

Chemical Name:N-(4-bromo-2-nitro-6-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide
CAS No.:1384979-49-0
Molecular Formula:C₁₂H₁₀BrF₃N₂O₄
Molecular Weight:383.122
Hs Code.:

Synonyms:N-(4-bromo-2-nitro-6-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

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Chemical Property of N-(4-bromo-2-nitro-6-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

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Technology Process of N-(4-bromo-2-nitro-6-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

There total 6 articles about N-(4-bromo-2-nitro-6-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1384979-48-9
4-bromo-2-tetrahydrofuran-2-yl-aniline

: 407-25-0
trifluoroacetic anhydride

: 1384979-49-0
N-(4-bromo-2-nitro-6-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: 4-bromo-2-tetrahydrofuran-2-yl-aniline; trifluoroacetic anhydride; With 2-methyltetrahydrofuran; at 20 ℃; Cooling with ice;

With ammonium nitrate; at 20 - 40 ℃; for 1.16667h;

Reference yield: 62.0%

: 96-47-9
2-methyltetrahydrofuran

: 1384979-48-9
4-bromo-2-tetrahydrofuran-2-yl-aniline

: 1384979-49-0
N-(4-bromo-2-nitro-6-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: With ammonium nitrate; trifluoroacetic anhydride;

Reference yield:

: 577-19-5
2-nitrophenyl bromide

: 1384979-49-0
N-(4-bromo-2-nitro-6-tetrahydrofuran-2-yl-phenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / palladium diacetate; (R)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine ethanol adduct / 1,4-dioxane / 105 °C / Inert atmosphere; Sealed tube

1.2: 20 °C / 1551.49 Torr

2.1: N-Bromosuccinimide / acetonitrile; tert-butyl methyl ether / 0.5 h / 2 - 8 °C

3.1: ammonium nitrate / 2-methyltetrahydrofuran / 1.42 h / 2 - 40 °C

With N-Bromosuccinimide; ammonium nitrate; potassium carbonate; (R)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine ethanol adduct; palladium diacetate; In 2-methyltetrahydrofuran; 1,4-dioxane; tert-butyl methyl ether; acetonitrile; 1.1: Heck coupling;