<<3-(2R,4S,5S),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone

Base Information

• Chemical Name: <<3-(2R,4S,5S),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone
• CAS No.: 141505-92-2
• Molecular Formula: C₂₀H₂₇NO₅
• Molecular Weight: 361.438
• Mol file: 141505-92-2.mol

Synonyms:<<3-(2R,4S,5S),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone

Chemical Property of <<3-(2R,4S,5S),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <<3-(2R,4S,5S),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone

There total 1 articles about <<3-(2R,4S,5S),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-methylpentane-1,3-dione (101712-01-0,141423-22-5,141423-21-4) + isobutyraldehyde (78-84-2) → <<3-(2R,4R,5R),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone (141505-95-5) + <<3-(2R,4S,5S),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone (141505-92-2)

Guidance literature:

In diethyl ether; Mechanism; multistep reaction: 1) (c-hex)2BCl, EtNMe₂, 0 deg C, 1 h, 2) -78 deg C, 3 h, 3) -78 to -20 deg C, 2 h INO 910 react in the same way with other aldehydes;

DOI:10.1016/S0040-4020(01)88879-7

Reference yield: 81.0%

<<3-(2R,4S,5S),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone (141505-92-2) → <<3-(2R,3R,4S,5S),4R>-3-(3,5-Dihydrox-2,4,6-trimethyl-1-oxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone (141506-01-6)

Guidance literature:

With acetic acid; tetramethylammonium triacetoxyborohydride; In acetonitrile; for 2.75h; Ambient temperature;

DOI:10.1016/S0040-4020(01)88879-7

Reference yield: 70.0%

<<3-(2R,4S,5S),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone (141505-92-2) → <<3-(2R,3R,4S,5S),4R>-3-(3,5-Dihydrox-2,4,6-trimethyl-1-oxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone (141506-01-6) + <<3-(2R,3S,4S,5S),4R>-3-(3,5-Dihyrdoxy-2,4,6-trimethyl-1-oxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone (124356-88-3,124439-39-0,141506-01-6,141506-02-7)

Guidance literature:

With zinc(II) tetrahydroborate; In dichloromethane; at -78 ℃; for 1h;

DOI:10.1016/S0040-4020(01)88879-7

upstream raw materials:

(R)-1-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-methylpentane-1,3-dione

isobutyraldehyde

Downstream raw materials:

<<3-(2R,3R,4S,5S),4R>-3-(3,5-Dihydrox-2,4,6-trimethyl-1-oxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone

<<3-(2R,3S,4S,5S),4R>-3-(3,5-Dihyrdoxy-2,4,6-trimethyl-1-oxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone

<<3-(2S,4R,5R),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidinone

<<3-(2S,4S,5S),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-heptyl)-4-(phenylmethyl)>-2-oxazolidone