1-benzyl-4-(2-(4-(phenylsulfonyl)phenyl)-2-(prop-2-yn-1-yloxy)propyl)-1H-1,2,3-triazole

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Chemical Name:1-benzyl-4-(2-(4-(phenylsulfonyl)phenyl)-2-(prop-2-yn-1-yloxy)propyl)-1H-1,2,3-triazole
CAS No.:1621085-08-2
Molecular Formula:C₂₇H₂₅N₃O₃S
Molecular Weight:471.58
Hs Code.:

Synonyms:1-benzyl-4-(2-(4-(phenylsulfonyl)phenyl)-2-(prop-2-yn-1-yloxy)propyl)-1H-1,2,3-triazole

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Chemical Property of 1-benzyl-4-(2-(4-(phenylsulfonyl)phenyl)-2-(prop-2-yn-1-yloxy)propyl)-1H-1,2,3-triazole

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Technology Process of 1-benzyl-4-(2-(4-(phenylsulfonyl)phenyl)-2-(prop-2-yn-1-yloxy)propyl)-1H-1,2,3-triazole

There total 3 articles about 1-benzyl-4-(2-(4-(phenylsulfonyl)phenyl)-2-(prop-2-yn-1-yloxy)propyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1621085-06-0
1-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(4-(phenylsulfonyl)phenyl)propan-2-ol

: 106-96-7
propargyl bromide

: 1621085-08-2
1-benzyl-4-(2-(4-(phenylsulfonyl)phenyl)-2-(prop-2-yn-1-yloxy)propyl)-1H-1,2,3-triazole

Guidance literature:: 1-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(4-(phenylsulfonyl)phenyl)propan-2-ol; With sodium hydride; In N,N-dimethyl-formamide; at -20 ℃;

propargyl bromide; In N,N-dimethyl-formamide; at -20 ℃; for 0.5h; Sonication;
DOI:10.1016/j.ejmech.2014.07.042

Reference yield:

: 1621085-04-8
2-(4-(phenylsulfonyl)phenyl)pent-4-yn-2-ol

: 1621085-08-2
1-benzyl-4-(2-(4-(phenylsulfonyl)phenyl)-2-(prop-2-yn-1-yloxy)propyl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 0.33 h / 25 - 30 °C / Sonication; Green chemistry

2.1: sodium hydride / N,N-dimethyl-formamide / -20 °C

2.2: 0.5 h / -20 °C / Sonication

With copper(ll) sulfate pentahydrate; sodium hydride; sodium L-ascorbate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2014.07.042

Reference yield:

: 65085-83-8
4'-(phenylsulfonyl)acetophenone

: 1621085-08-2
1-benzyl-4-(2-(4-(phenylsulfonyl)phenyl)-2-(prop-2-yn-1-yloxy)propyl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc; zinc dibromide / tetrahydrofuran / 1.5 h / 25 - 30 °C / Sonication

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 0.33 h / 25 - 30 °C / Sonication; Green chemistry

3.1: sodium hydride / N,N-dimethyl-formamide / -20 °C

3.2: 0.5 h / -20 °C / Sonication

With copper(ll) sulfate pentahydrate; sodium hydride; sodium L-ascorbate; zinc dibromide; zinc; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: |Barbier Coupling Reaction;
DOI:10.1016/j.ejmech.2014.07.042