Technology Process of 5-(2,3-Difluoro-4-methoxyphenyl)-4,4-dimethyl-2,4-dihydropyrazol-3-one
There total 7 articles about 5-(2,3-Difluoro-4-methoxyphenyl)-4,4-dimethyl-2,4-dihydropyrazol-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrazine hydrate; acetic acid;
In
ethanol;
for 10h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 °C
2.1: borane-THF / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere
2.2: 6 h / 60 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide; acetone / 5.5 h / 20 °C
5.1: boron trifluoride diethyl etherate / diethyl ether / 1 h / 20 °C / Inert atmosphere
6.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 20 °C
7.1: hydrazine hydrate / ethanol / 6 h / Reflux
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; borane-THF; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium carbonate; hydrazine hydrate; triethylamine;
In
tetrahydrofuran; diethyl ether; ethanol; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2012.08.121
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide; acetone / 5.5 h / 20 °C
3: boron trifluoride diethyl etherate / diethyl ether / 1 h / 20 °C / Inert atmosphere
4: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 20 °C
5: hydrazine hydrate / ethanol / 6 h / Reflux
With
boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium carbonate; hydrazine hydrate; triethylamine;
In
tetrahydrofuran; diethyl ether; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2012.08.121
