Technology Process of methyl 3-(2,3-difluoro-4-methoxyphenyl)-2,2-dimethyl-3-oxopropanoate
There total 7 articles about methyl 3-(2,3-difluoro-4-methoxyphenyl)-2,2-dimethyl-3-oxopropanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sulfur trioxide pyridine complex; triethylamine;
In
dimethyl sulfoxide;
at 20 ℃;
for 1h;
DOI:10.1016/j.bmcl.2012.08.121
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
1.2: 0.5 h / -78 °C
2.1: borane-THF / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere
2.2: 6 h / 60 °C
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
4.1: potassium carbonate / N,N-dimethyl-formamide; acetone / 5.5 h / 20 °C
5.1: boron trifluoride diethyl etherate / diethyl ether / 1 h / 20 °C / Inert atmosphere
6.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 20 °C
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; borane-THF; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium carbonate; triethylamine;
In
tetrahydrofuran; diethyl ether; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2012.08.121
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: borane-THF / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere
1.2: 6 h / 60 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide; acetone / 5.5 h / 20 °C
4.1: boron trifluoride diethyl etherate / diethyl ether / 1 h / 20 °C / Inert atmosphere
5.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 1 h / 20 °C
With
borane-THF; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium carbonate; triethylamine;
In
tetrahydrofuran; diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2012.08.121
