(5R)-tert-butoxycarbonylamino-(4R)-[hydroxy-(2,4-dimethoxybenzyl)-amino]-(6S)-methoxy-(6S)-methylnon-2-ynoic acid ethyl ester

Base Information

Chemical Name:(5R)-tert-butoxycarbonylamino-(4R)-[hydroxy-(2,4-dimethoxybenzyl)-amino]-(6S)-methoxy-(6S)-methylnon-2-ynoic acid ethyl ester
CAS No.:433711-87-6
Molecular Formula:C₂₇H₄₂N₂O₈
Molecular Weight:522.639
Hs Code.:

Synonyms:(5R)-tert-butoxycarbonylamino-(4R)-[hydroxy-(2,4-dimethoxybenzyl)-amino]-(6S)-methoxy-(6S)-methylnon-2-ynoic acid ethyl ester

Suppliers and Price of (5R)-tert-butoxycarbonylamino-(4R)-[hydroxy-(2,4-dimethoxybenzyl)-amino]-(6S)-methoxy-(6S)-methylnon-2-ynoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5R)-tert-butoxycarbonylamino-(4R)-[hydroxy-(2,4-dimethoxybenzyl)-amino]-(6S)-methoxy-(6S)-methylnon-2-ynoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R)-tert-butoxycarbonylamino-(4R)-[hydroxy-(2,4-dimethoxybenzyl)-amino]-(6S)-methoxy-(6S)-methylnon-2-ynoic acid ethyl ester

There total 8 articles about (5R)-tert-butoxycarbonylamino-(4R)-[hydroxy-(2,4-dimethoxybenzyl)-amino]-(6S)-methoxy-(6S)-methylnon-2-ynoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 623-47-2
propynoic acid ethyl ester

: 433711-86-5
C₂₂H₃₆N₂O₆

: 433711-87-6
(5R)-tert-butoxycarbonylamino-(4R)-[hydroxy-(2,4-dimethoxybenzyl)-amino]-(6S)-methoxy-(6S)-methylnon-2-ynoic acid ethyl ester

Guidance literature:: propynoic acid ethyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

C₂₂H₃₆N₂O₆; With boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Further stages.;
DOI:10.1021/ja0126226

Reference yield:

: 167102-62-7,1822572-30-4
(R)-N,O-isopropylidenyl-2-(N-tert-butyloxycarbonylamino)-3-oxo-propanamide-N,O-dimethyl-hydroxyamine

: 433711-87-6
(5R)-tert-butoxycarbonylamino-(4R)-[hydroxy-(2,4-dimethoxybenzyl)-amino]-(6S)-methoxy-(6S)-methylnon-2-ynoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 93 percent / tetrahydrofuran / 1 h / -65 °C

2.1: 99 percent / H₂ / Pd/C / methanol / 14 h / 20 °C / atmospheric pressure

3.1: 92 percent / tetrahydrofuran / -78 - 20 °C

4.1: 99 percent / NaH; Bu₄NI / dimethylformamide / 16 h / 20 °C

5.1: 90 percent / p-TsOH; methanol / 0.5 h / 20 °C

6.1: SO₃*pyridine; Et₃N; DMSO / CH₂Cl₂ / 2 h / 20 °C

7.1: 93 percent / MgSO₄ / CH₂Cl₂ / 4 h / 20 °C

8.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

8.2: 85 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 1 h / -78 °C

With methanol; n-butyllithium; pyridine-SO₃ complex; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 6.1: Parikh-Doering oxidation;
DOI:10.1021/ja0126226

Reference yield:

: 176108-62-6
(R)-4-but-3-enoyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 433711-87-6
(5R)-tert-butoxycarbonylamino-(4R)-[hydroxy-(2,4-dimethoxybenzyl)-amino]-(6S)-methoxy-(6S)-methylnon-2-ynoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 99 percent / H₂ / Pd/C / methanol / 14 h / 20 °C / atmospheric pressure

2.1: 92 percent / tetrahydrofuran / -78 - 20 °C

3.1: 99 percent / NaH; Bu₄NI / dimethylformamide / 16 h / 20 °C

4.1: 90 percent / p-TsOH; methanol / 0.5 h / 20 °C

5.1: SO₃*pyridine; Et₃N; DMSO / CH₂Cl₂ / 2 h / 20 °C

6.1: 93 percent / MgSO₄ / CH₂Cl₂ / 4 h / 20 °C

7.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

7.2: 85 percent / BF₃*Et₂O / tetrahydrofuran; hexane / 1 h / -78 °C

With methanol; n-butyllithium; pyridine-SO₃ complex; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; magnesium sulfate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 5.1: Parikh-Doering oxidation;
DOI:10.1021/ja0126226