methyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

Base Information

Chemical Name:methyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate
CAS No.:915771-78-7
Molecular Formula:C₂₁H₂₃NO₆
Molecular Weight:385.417
Hs Code.:

Synonyms:methyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

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Chemical Property of methyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

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Technology Process of methyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

There total 7 articles about methyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 915771-73-2
methyl 3-hydroxy-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

: 915771-78-7
methyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

: 915771-79-8
1-methylethyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

Guidance literature:: 2-iodo-propane; methyl 3-hydroxy-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate; With caesium carbonate; In ISOPROPYLAMIDE; at 140 ℃; for 2h; Microwave;

With hydrogenchloride; In water; ethyl acetate;

methanol; With thionyl chloride; at -35 - 20 ℃; for 19h;

Reference yield:

: 2150-44-9
1-carbomethoxy-3,5-dihydroxybenzene

: 915771-78-7
methyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

: 915771-79-8
1-methylethyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: caesium carbonate / acetonitrile / 8 h / 160 °C / Microwave

2.2: pH 2

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Heating / reflux

4.1: caesium carbonate / ISOPROPYLAMIDE / 2 h / 140 °C / Microwave

4.3: 19 h / -35 - 20 °C

With ammonium formate; potassium carbonate; caesium carbonate; palladium 10% on activated carbon; In methanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 157373-00-7
3-chloro-2,4-difluoro-benzoyl chloride

: 915771-78-7
methyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

: 915771-79-8
1-methylethyl 3-[(1-methylethyl)oxy]-5-[(4-methyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepin-8-yl)oxy]benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / dichloromethane; water / 4 h / 0 - 20 °C

2.1: caesium carbonate / acetonitrile / 8 h / 160 °C / Microwave

2.2: pH 2

3.1: thionyl chloride / 19 h / -35 - 20 °C

4.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Heating / reflux

5.1: caesium carbonate / ISOPROPYLAMIDE / 2 h / 140 °C / Microwave

5.3: 19 h / -35 - 20 °C

With sodium hydroxide; thionyl chloride; ammonium formate; caesium carbonate; palladium 10% on activated carbon; In methanol; dichloromethane; ISOPROPYLAMIDE; water; acetonitrile;