C₂₆H₄₄O₅SiS

Base Information

• Chemical Name: C₂₆H₄₄O₅SiS
• CAS No.: 934623-87-7
• Molecular Formula: C₂₆H₄₄O₅SSi
• Molecular Weight: 496.784
• Mol file: 934623-87-7.mol

Synonyms:C₂₆H₄₄O₅SiS

Chemical Property of C₂₆H₄₄O₅SiS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₄₄O₅SiS

There total 8 articles about C₂₆H₄₄O₅SiS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-3-[1-(tert-butyl)-1,1-dimethylsilyl]oxy-2-methylpropyl phenyl sulfone (220018-34-8) + 1-[(2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-2-pyranyl]-1-ethanone (393530-60-4) → C26H44O5SiS (934623-87-7)

Guidance literature:

(2R)-3-[1-(tert-butyl)-1,1-dimethylsilyl]oxy-2-methylpropyl phenyl sulfone; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

1-[(2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-2-pyranyl]-1-ethanone; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Further stages.;

DOI:10.1021/ja0691728

Reference yield:

tert-butyl[((1S,2R)-2-[(1R)-1-ethyl-2-methyl-2-propenyl]oxy-1-methyl-4-pentenyl)oxy]dimethylsilane (902769-02-2) → C26H44O5SiS (934623-87-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 94 percent / Grubbs catalyst / CH₂Cl₂ / 15 h / Heating

2.1: 94 percent / TBAF / tetrahydrofuran / 3 h / 20 °C

3.1: 95 percent / NaHCO₃; Dess-Martin reagent / CH₂Cl₂ / 0 - 20 °C

4.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: tetrahydrofuran; hexane / 2 h / -78 °C

With Grubbs catalyst first generation; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ja0691728

Reference yield:

1-(tert-butyl)-1,1-dimethylsilyl (1S)-1-[(2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-2-pyranyl]ethyl ether (902769-10-2) → C26H44O5SiS (934623-87-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 94 percent / TBAF / tetrahydrofuran / 3 h / 20 °C

2.1: 95 percent / NaHCO₃; Dess-Martin reagent / CH₂Cl₂ / 0 - 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: tetrahydrofuran; hexane / 2 h / -78 °C

With n-butyllithium; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/ja0691728

upstream raw materials:

(2R)-3-[1-(tert-butyl)-1,1-dimethylsilyl]oxy-2-methylpropyl phenyl sulfone

1-[(2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-2-pyranyl]-1-ethanone

1-(tert-butyl)-1,1-dimethylsilyl (1S)-1-[(2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-2-pyranyl]ethyl ether

(1S)-1-[(2R,6R)-6-ethyl-5-methyl-3,6-dihydro-2H-2-pyranyl]ethan-1-ol

Downstream raw materials:

C₃₃H₄₈O₆SiS