methanesulfonic acid 2-benzyloxy-1-[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-ethyl ester

Base Information

Chemical Name:methanesulfonic acid 2-benzyloxy-1-[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-ethyl ester
CAS No.:247089-09-4
Molecular Formula:C₂₂H₃₅NO₆S
Molecular Weight:441.589
Hs Code.:

Synonyms:methanesulfonic acid 2-benzyloxy-1-[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-ethyl ester

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Chemical Property of methanesulfonic acid 2-benzyloxy-1-[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-ethyl ester

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Technology Process of methanesulfonic acid 2-benzyloxy-1-[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-ethyl ester

There total 9 articles about methanesulfonic acid 2-benzyloxy-1-[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 124-63-0
methanesulfonyl chloride

: 247089-08-3
[1-(2-benzyloxy-1-hydroxy-ethyl)-cyclohexylmethyl]-carbamic acid tert-butyl ester

: 247089-09-4
methanesulfonic acid 2-benzyloxy-1-[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at -10 - 20 ℃; for 36h;
DOI:10.1016/j.bmcl.2013.09.068

Reference yield: 57.0%

: 124-63-0
methanesulfonyl chloride

: 247089-25-4
1-oxo-octahydro-isoindole-2-carboxylic acid tert-butyl ester

: (+/-)-2-Aza-spiro[4.5]decane-4-carboxylic acid hydrochloride

: 247089-09-4
methanesulfonic acid 2-benzyloxy-1-[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-ethyl ester

Guidance literature:: With triethylamine; In diethyl ether; dichloromethane;

Reference yield:

: 247089-06-1
1-(2-Benzyloxy-1-hydroxy-ethyl)-cyclohexanecarbonitrile

: 247089-09-4
methanesulfonic acid 2-benzyloxy-1-[1-(tert-butoxycarbonylamino-methyl)-cyclohexyl]-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / LiAlH₄, AlCl₃ / diethyl ether

2: 96 percent / CH₂Cl₂

3: 65 percent / Et₃N / CH₂Cl₂

With lithium aluminium tetrahydride; aluminium trichloride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1016/S0960-894X(99)00383-2