N-<2-<(p-nitrobenzyl)amino>ethyl>-5-isoquinolinesulfonamide dihydrochloride

Base Information

• Chemical Name: N-<2-<(p-nitrobenzyl)amino>ethyl>-5-isoquinolinesulfonamide dihydrochloride
• CAS No.: 116970-61-7
• Molecular Formula: C₁₈H₁₈N₄O₄S*2ClH
• Molecular Weight: 459.353
• Mol file: 116970-61-7.mol

Synonyms:N-<2-<(p-nitrobenzyl)amino>ethyl>-5-isoquinolinesulfonamide dihydrochloride

Chemical Property of N-<2-<(p-nitrobenzyl)amino>ethyl>-5-isoquinolinesulfonamide dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-<(p-nitrobenzyl)amino>ethyl>-5-isoquinolinesulfonamide dihydrochloride

There total 3 articles about N-<2-<(p-nitrobenzyl)amino>ethyl>-5-isoquinolinesulfonamide dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-(2-aminoethyl)-5-isoquinoline-sulphonamide hydrochloride (116970-50-4) + 1-bromomethyl-4-nitro-benzene (100-11-8) → N-<2-<(p-nitrobenzyl)amino>ethyl>-5-isoquinolinesulfonamide dihydrochloride (116970-61-7)

Guidance literature:

With potassium carbonate; In tetrahydrofuran;

DOI:10.1021/jm00121a010

Reference yield:

isoquinoline-5-sulfonic acid (27655-40-9) → N-<2-<(p-nitrobenzyl)amino>ethyl>-5-isoquinolinesulfonamide dihydrochloride (116970-61-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / SOCl₂, DMF / 2 h / Heating

2: 71 percent / NaHCO₃ / 1) H₂O, 2) CH₂Cl₂, RT, 1 h

3: 72 percent / K₂CO₃ / tetrahydrofuran

With thionyl chloride; sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1021/jm00121a010

Reference yield:

isoquinoline-5-sulfonyl chloride hydrochloride (105627-79-0) → N-<2-<(p-nitrobenzyl)amino>ethyl>-5-isoquinolinesulfonamide dihydrochloride (116970-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / NaHCO₃ / 1) H₂O, 2) CH₂Cl₂, RT, 1 h

2: 72 percent / K₂CO₃ / tetrahydrofuran

With sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran;

DOI:10.1021/jm00121a010

upstream raw materials:

N-(2-aminoethyl)-5-isoquinoline-sulphonamide hydrochloride

1-bromomethyl-4-nitro-benzene

isoquinoline-5-sulfonic acid

isoquinoline-5-sulfonyl chloride hydrochloride