116970-50-4

Basic information

• Product Name: H-9
• Synonyms: n-(2-aminoethyl)-5-isoquinolinesulfonamidemonohydrochloride;n-(2-aminoethyl)-5-isoquinolinesulfonamidmonohydrochloride;N-(2-AMINOETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE;N-(2-AMINOETHYL)ISOQUINOLINE-5-SULFONAMIDE HYDROCHLORIDE;H-9;N-(2-AMINOETHYL)-ISOCHINOLINE-5-SULFONAMIDE HYDROCHLORIDE;N-(2-Aminoethyl)-5-isoquinolinesulfonamide, Dihydrochloride Discontinued See: A609001;N-(2-AMINOETHYL)ISOQUINOLINE-5-SULFONAMIDE HYDROCHLORIDE (H9)
• CAS NO: 116970-50-4
• Molecular Formula: C₁₁H₁₃N₃O₂S*ClH
• Molecular Weight: 287.77
• Product Categories: Chemical Amines;Amines;Heterocycles;Inhibitors;Protein Kinase Inhibitors and Activators
• Mol File: 116970-50-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 250-255°C (dec)
• Boiling Point: 479.8 °C at 760 mmHg
• Flash Point: 243.9 °C
• Appearance: White crystalline solid
• Vapor Pressure: 2.3E-09mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: H-9(CAS DataBase Reference)
• NIST Chemistry Reference: H-9(116970-50-4)
• EPA Substance Registry System: H-9(116970-50-4)

Safety Data

• Hazard Codes: Xi,Xn,T
• Statements: 36/37/38-20/21/22-61
• Safety Statements: 26-36-45-53
• WGK Germany: 3
• RTECS: NX4897000
• Hazardous Substances Data: 116970-50-4(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

InChI:InChI=1/C11H13N3O2S.ClH/c12-5-7-14-17(15,16)11-3-1-2-9-8-13-6-4-10(9)11;/h1-4,6,8,14H,5,7,12H2;1H

Upstream product

• 84468-15-5 5-isoquinolinesulfonyl chloride 
• 107-15-3 ethylenediamine 
• 27655-40-9 isoquinoline-5-sulfonic acid 
• 105627-79-0 isoquinoline-5-sulfonyl chloride hydrochloride 

Downstream Products

• 105628-07-7 fasudil hydrochloride 
• 116970-61-7 N-<2-<(p-nitrobenzyl)amino>ethyl>-5-isoquinolinesulfonamide dihydrochloride 
• 116970-59-3 Isoquinoline-5-sulfonic acid [2-(3-chloro-benzylamino)-ethyl]-amide; hydrochloride 
• 116970-58-2 Isoquinoline-5-sulfonic acid [2-(4-chloro-benzylamino)-ethyl]-amide; hydrochloride 
• 116970-60-6 Isoquinoline-5-sulfonic acid [2-(2-chloro-benzylamino)-ethyl]-amide; hydrochloride 

Relevant articles and documents

Preparation method of compound fasudil hydrochloride

The invention relates to a novel efficient and economical method for synthesizing fasudil hydrochloride. The method comprises the following steps: carrying outsulfonamide and Boc protection on cheap and easily available ethylenediamine serving as a starting raw material in a synthesis route to obtain an intermediate tert-butyl-(N-(2-aminoethyl)-5-isoquinoline sulfonamide) carbamate (5), and carrying out collapse condensation to obtain fasudil hydrochloride. The method comprises four steps of nucleophilic substitution, deprotection, cyclization and salification. The total yield of the fasudil hydrochloride (1) is 67.1%, and the purity of the fasudil hydrochloride (1) is as high as 99.94%. Compared with a traditional process, high-price homopiperazine and derivatives thereof are prevented from being used as synthesis intermediates in the route, so the method has the advantages that raw materials are cheap and easy to obtain, operation is easy, cost is low, and the process is environmentally friendly and suitable for industrial production.