C₂₀H₂₇FO₄

Base Information

• Chemical Name: C₂₀H₂₇FO₄
• CAS No.: 1421319-75-6
• Molecular Formula: C₂₀H₂₇FO₄
• Molecular Weight: 350.43
• Mol file: 1421319-75-6.mol

Synonyms:C₂₀H₂₇FO₄

Chemical Property of C₂₀H₂₇FO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₇FO₄

There total 7 articles about C₂₀H₂₇FO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one (1421319-67-6) → C20H27FO4 (1421319-75-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 30 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol303351y

Reference yield:

7-iodo-1,4-dioxaspiro[4.5]dec-6-en-8-one (1374219-14-3) → C20H27FO4 (1421319-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; sodium carbonate / water; 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

2: hydrogen; 5%-palladium/activated carbon / ethanol / 12 h / 30 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; sodium carbonate; lithium chloride; In 1,2-dimethoxyethane; ethanol; water; 1: |Suzuki Coupling;

DOI:10.1021/ol303351y

Reference yield:

1-bromo-3-fluoro-5-methoxybenzene (29578-39-0) → C20H27FO4 (1421319-75-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 6 h / 90 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; sodium carbonate / water; 1,2-dimethoxyethane / 24 h / 80 °C / Inert atmosphere

4.1: hydrogen; 5%-palladium/activated carbon / ethanol / 12 h / 30 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; tert.-butyl lithium; sodium carbonate; potassium carbonate; lithium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; toluene; pentane; 3.1: |Suzuki Coupling;

DOI:10.1021/ol303351y

upstream raw materials:

1,4-dioxa-spiro[4.5]dec-6-en-8-one

7-iodo-1,4-dioxaspiro[4.5]dec-6-en-8-one

n-pentylboronic acid

7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]dec-6-en-8-one

Downstream raw materials:

(Z)-(R)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-8-(methoxymethylene)-1,4-dioxaspiro[4.5]decane

(E)-(R)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-8-(methoxymethylene)-1,4-dioxaspiro[4.5]decane

(7S,8S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-ol

(S)-7-(2-fluoro-6-methoxy-4-pentylphenyl)-1,4-dioxaspiro[4.5]decan-8-one