2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester

Base Information

• Chemical Name: 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester
• CAS No.: 6274-50-6
• Molecular Formula: C12H16 O3
• Molecular Weight: 208.257
• Hs Code.: 2918990090
• Mol file: 6274-50-6.mol

Synonyms:Hydratropicacid, p-methoxy-a-methyl-,methyl ester (8CI); NSC 37500

Chemical Property of 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester

Chemical Property:

• Vapor Pressure: 0.00429mmHg at 25°C
• Boiling Point: 278.3°C at 760 mmHg
• Flash Point: 111.7°C
• PSA: 35.53000
• Density: 1.04g/cm³
• LogP: 2.14580
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-(4-methoxyphenyl)-2-methylpropanoate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester

There total 9 articles about 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-methoxy-phenyl acetic acid methyl ester (23786-14-3) + methyl iodide (74-88-4) → methyl 2-(4-methoxyphenyl)-2-methylpropanoate (6274-50-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

Reference yield: 90.0%

1-bromo-4-methoxy-benzene (104-92-7) + Methyl isobutyrate (547-63-7,133320-07-7,67505-84-4) → methyl 2-(4-methoxyphenyl)-2-methylpropanoate (6274-50-6)

Guidance literature:

With tri-tert-butyl phosphine; lithium dicyclohexylamide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 20 ℃; for 24h;

DOI:10.1021/ja027643u

Reference yield: 88.0%

1-bromo-4-methoxy-benzene (104-92-7) + 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene (31469-15-5) → methyl 2-(4-methoxyphenyl)-2-methylpropanoate (6274-50-6)

Guidance literature:

With zinc(II) fluoride; tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

DOI:10.1021/ja036792p

upstream raw materials:

4-methoxy-phenyl acetic acid methyl ester

methyl iodide

1-bromo-4-methoxy-benzene

Methyl isobutyrate

Downstream raw materials:

2-(4-methoxyphenyl)-2-methylpropanoic acid

methyl 2-(4-hydroxyphenyl)-2-methylpropanoate

methyl 2-(3-formyl-4-hydroxyphenyl)-2-methylpropanoate

2-(4-methoxy-phenyl)-2-methyl-propionyl chloride

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