Technology Process of (R)-1,1,1-trifluoropropan-2-yl 4-((1r,4r)-4-(3-ethynylpyridin-4-yloxy)cyclohexyloxy)piperidine-1-carboxylate
There total 12 articles about (R)-1,1,1-trifluoropropan-2-yl 4-((1r,4r)-4-(3-ethynylpyridin-4-yloxy)cyclohexyloxy)piperidine-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
ethanol;
at 20 ℃;
for 5h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: sodium t-butanolate / dimethyl sulfoxide / 4 h / 40 - 80 °C
2.1: hydrogenchloride; water / 50 °C
2.2: 0.17 h / 20 °C / pH 6
2.3: 0.17 h / pH 7 - 8
3.1: sodium tetrahydroborate; methanol / 11 - 36 °C
3.2: 0.5 h
3.3: pH 8
4.1: ISOPROPYLAMIDE; tetrahydrofuran
5.1: sodium tetrahydroborate; methanol / 20 °C / Cooling with ice
6.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 2585.81 Torr
7.1: potassium tert-butylate / tetrahydrofuran / 5 h / 20 °C
8.1: N-ethyl-N,N-diisopropylamine; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 1 h / 20 °C
8.2: 20 °C
9.1: tetrahydrofuran / 2 h / 60 °C
9.2: 4 h / Reflux
10.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 48 h / 20 °C / Inert atmosphere
11.1: potassium carbonate / ethanol / 5 h / 20 °C / Inert atmosphere
With
hydrogenchloride; methanol; sodium tetrahydroborate; copper(l) iodide; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium t-butanolate;
bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: sodium t-butanolate / dimethyl sulfoxide / 4 h / 40 - 80 °C
2.1: hydrogenchloride; water / 50 °C
2.2: 0.17 h / 20 °C / pH 6
2.3: 0.17 h / pH 7 - 8
3.1: sodium tetrahydroborate; methanol / 11 - 36 °C
3.2: 0.5 h
3.3: pH 8
4.1: ISOPROPYLAMIDE; tetrahydrofuran
5.1: sodium tetrahydroborate; methanol / 20 °C / Cooling with ice
6.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 2585.81 Torr
7.1: potassium tert-butylate / tetrahydrofuran / 5 h / 20 °C
8.1: N-ethyl-N,N-diisopropylamine; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 1 h / 20 °C
8.2: 20 °C
9.1: tetrahydrofuran / 2 h / 60 °C
9.2: 4 h / Reflux
10.1: triethylamine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 48 h / 20 °C / Inert atmosphere
11.1: potassium carbonate / ethanol / 5 h / 20 °C / Inert atmosphere
With
hydrogenchloride; methanol; sodium tetrahydroborate; copper(l) iodide; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; water; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium t-butanolate;
bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; dimethyl sulfoxide;
