N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-methoxyethanesulfonamide

Base Information

Chemical Name:N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-methoxyethanesulfonamide
CAS No.:1295574-97-8
Molecular Formula:C₂₃H₂₄F₂IN₃O₆S₂
Molecular Weight:667.493
Hs Code.:

Synonyms:N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-methoxyethanesulfonamide

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Chemical Property of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-methoxyethanesulfonamide

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Technology Process of N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-methoxyethanesulfonamide

There total 6 articles about N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-methoxyethanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51517-01-2
2-methoxyethane-1-sulfonyl chloride

: 1295567-67-7
N-(3-{2-amino-5-fluoro-3-[(2-fluoro-4-iodophenyl)amino]phenoxy}phenyl)ethanesulfonamide

: 1295574-97-8
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-methoxyethanesulfonamide

Guidance literature:: With pyridine; at 20 ℃;

Reference yield:

: 29632-74-4
2-fluro-4-iodoaniline

: 1295574-97-8
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-methoxyethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2.2: 20 h / 20 °C / Inert atmosphere

2.3: 3 h / 50 °C

3.1: pyridine / 20 °C

With pyridine; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 315-14-0
1,3,5-trifluoro-2-nitrobenzene

: 1295574-97-8
N-(2-{3-[(ethylsulfonyl)amino]phenoxy}-4-fluoro-6-[(2-fluoro-4-iodophenyl)amino]phenyl)-2-methoxyethanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 121 h / -10 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2.2: 20 h / 20 °C / Inert atmosphere

2.3: 3 h / 50 °C

3.1: pyridine / 20 °C

With pyridine; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;