diethyl N-benzyloxycarbonyl-L-phenylalanyl-1-amino-2-hydroxypropane phosphonate

Base Information

Chemical Name:diethyl N-benzyloxycarbonyl-L-phenylalanyl-1-amino-2-hydroxypropane phosphonate
CAS No.:227796-96-5
Molecular Formula:C₂₄H₃₃N₂O₇P
Molecular Weight:492.509
Hs Code.:

Synonyms:diethyl N-benzyloxycarbonyl-L-phenylalanyl-1-amino-2-hydroxypropane phosphonate

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Chemical Property of diethyl N-benzyloxycarbonyl-L-phenylalanyl-1-amino-2-hydroxypropane phosphonate

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Technology Process of diethyl N-benzyloxycarbonyl-L-phenylalanyl-1-amino-2-hydroxypropane phosphonate

There total 3 articles about diethyl N-benzyloxycarbonyl-L-phenylalanyl-1-amino-2-hydroxypropane phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1161-13-3
N-Cbz-L-Phe

: 541-41-3
chloroformic acid ethyl ester

: 227796-94-3
diethyl 1-amino-2-hydroxypropanephosphonate

: 227796-96-5
diethyl N-benzyloxycarbonyl-L-phenylalanyl-1-amino-2-hydroxypropane phosphonate

Guidance literature:: With triethylamine; In tetrahydrofuran; chloroform; at 20 ℃;
DOI:10.1080/10426509808029670

Reference yield:

: 1067-71-6
Diethyl (2-oxopropyl)phosphonate

: 227796-96-5
diethyl N-benzyloxycarbonyl-L-phenylalanyl-1-amino-2-hydroxypropane phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: NaOAc; NaHCO₃ / pH 7

2: H₂ / Raney-Ni / 20 °C / 750060 Torr

3: 53 percent / Et₃N / CHCl₃; tetrahydrofuran / 20 °C

With hydrogen; sodium acetate; sodium hydrogencarbonate; triethylamine; nickel; In tetrahydrofuran; chloroform; 1: Substitution / 2: Hydrogenolysis / 3: Acylation;
DOI:10.1080/10426509808029670

Reference yield:

: 4762-51-0
Acetyl-benzolazo-methylphosphonsaeure-diaethylester

: 227796-96-5
diethyl N-benzyloxycarbonyl-L-phenylalanyl-1-amino-2-hydroxypropane phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Raney-Ni / 20 °C / 750060 Torr

2: 53 percent / Et₃N / CHCl₃; tetrahydrofuran / 20 °C

With hydrogen; triethylamine; nickel; In tetrahydrofuran; chloroform; 1: Hydrogenolysis / 2: Acylation;
DOI:10.1080/10426509808029670