Technology Process of methyl (2S,3S)-(+)-2-bromo-3-hydroxy-3-(4-methoxyphenyl)propionate
There total 13 articles about methyl (2S,3S)-(+)-2-bromo-3-hydroxy-3-(4-methoxyphenyl)propionate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 85 percent / conc. aq. HCl, H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
2: 88 percent / Et3N / CH2Cl2 / Ambient temperature
3: 47 percent / aq. NaOH / ethanol / 0.5 h / Ambient temperature
4: 31 percent / CoCl2*6H2O / H2O / 6 h / 33 - 41 °C / aminoacylase, pH = 7.0
5: NaNO2, KBr, aq. H2SO4 / diethyl ether / 2 h / Ambient temperature
6: diethyl ether / 0.17 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; sulfuric acid; hydrogen; triethylamine; cobalt(II) chloride; potassium bromide; sodium nitrite;
palladium on activated charcoal;
In
diethyl ether; ethanol; dichloromethane; water;
DOI:10.1248/cpb.41.1521
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 88 percent / aq. NaNO2, AcOH / 2 h
2: 85 percent / conc. aq. HCl, H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
3: 88 percent / Et3N / CH2Cl2 / Ambient temperature
4: 47 percent / aq. NaOH / ethanol / 0.5 h / Ambient temperature
5: 31 percent / CoCl2*6H2O / H2O / 6 h / 33 - 41 °C / aminoacylase, pH = 7.0
6: NaNO2, KBr, aq. H2SO4 / diethyl ether / 2 h / Ambient temperature
7: diethyl ether / 0.17 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; sulfuric acid; hydrogen; acetic acid; triethylamine; cobalt(II) chloride; potassium bromide; sodium nitrite;
palladium on activated charcoal;
In
diethyl ether; ethanol; dichloromethane; water;
DOI:10.1248/cpb.41.1521