(R)-1-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-ethoxymethyl-1H-imidazol-4-yl}-phenoxy)-3-diethylamino-propan-2-ol

Base Information

Chemical Name:(R)-1-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-ethoxymethyl-1H-imidazol-4-yl}-phenoxy)-3-diethylamino-propan-2-ol
CAS No.:1284150-32-8
Molecular Formula:C₃₁H₃₆ClN₃O₄
Molecular Weight:550.098
Hs Code.:

Synonyms:(R)-1-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-ethoxymethyl-1H-imidazol-4-yl}-phenoxy)-3-diethylamino-propan-2-ol

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Chemical Property of (R)-1-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-ethoxymethyl-1H-imidazol-4-yl}-phenoxy)-3-diethylamino-propan-2-ol

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Technology Process of (R)-1-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-ethoxymethyl-1H-imidazol-4-yl}-phenoxy)-3-diethylamino-propan-2-ol

There total 6 articles about (R)-1-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-ethoxymethyl-1H-imidazol-4-yl}-phenoxy)-3-diethylamino-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1284150-05-5
1-[4-(4-chloro-phenoxy)-phenyl]-2-ethoxymethyl-4-[4-((R)-1-oxiranylmethoxy)-phenyl]-1H-imidazole

: 109-89-7
diethylamine

: 1284150-32-8
(R)-1-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-ethoxymethyl-1H-imidazol-4-yl}-phenoxy)-3-diethylamino-propan-2-ol

Guidance literature:: In tetrahydrofuran; at 60 ℃;

Reference yield:

: 13031-43-1
4-acetyloxyacetophenone

: 1284150-32-8
(R)-1-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-ethoxymethyl-1H-imidazol-4-yl}-phenoxy)-3-diethylamino-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridinium hydrobromide perbromide / 1,4-dioxane / 5 h

2.1: sodium hydrogencarbonate / methanol; dichloromethane

3.1: tetrahydrofuran / 0.08 h / -78 °C

3.2: 1 h / Cooling

4.1: ammonium acetate / acetic acid / 100 - 110 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C

6.1: tetrahydrofuran / 60 °C

With pyridinium hydrobromide perbromide; ammonium acetate; sodium hydrogencarbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 41104-10-3
acetic acid 4-(2-bromoacetyl)phenyl ester

: 1284150-32-8
(R)-1-(4-{1-[4-(4-chloro-phenoxy)-phenyl]-2-ethoxymethyl-1H-imidazol-4-yl}-phenoxy)-3-diethylamino-propan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / methanol; dichloromethane

2.1: tetrahydrofuran / 0.08 h / -78 °C

2.2: 1 h / Cooling

3.1: ammonium acetate / acetic acid / 100 - 110 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 80 °C

5.1: tetrahydrofuran / 60 °C

With ammonium acetate; sodium hydrogencarbonate; caesium carbonate; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;