41104-10-3Relevant articles and documents
One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid
de Andrade, Vitor S.C.,de Mattos, Marcio C.S.
supporting information, (2020/07/03)
A simple and efficient one-pot protocol has been developed for the conversion of styrenes into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric acid was successfully used for the co-bromination and oxidation of styrenes to give phenacyl bromides, which in the presence of thioureas produced the corresponding 4-aryl-2-aminothiazoles in 48–70% yield. The protocol involves three reactions in one process: a tandem (formation of phenacyl bromides from styrenes) followed by a telescoped (conversion to thiazole) reaction.
One-pot synthesis of α-bromo- and α-azidoketones from olefins by catalytic oxidation with in situ-generated modified IBX as the key reaction
Chandra, Ajeet,Parida, Keshaba Nanda,Moorthy, Jarugu Narasimha
, p. 5827 - 5832 (2017/09/09)
Simple one-pot protocols for the syntheses of α-bromoketones and α-azidoketones starting from olefins have been developed by employing catalytic oxidation of the intermediary bromohydrins with in situ-generated modified IBX as the key reaction. The improved procedure involves initial formation of bromohydrin by the reaction of olefin with NBS in acetonitrile-water mixture (1:1) at rt followed by oxidation with in situ-generated 3,4,5,6-tetramethyl-2-iodoxybenzoic acid (TetMe-IBX), produced in catalytic amounts from 3,4,5,6-tetramethyl-2-iodobenzoic and Oxone. α-Bromoketones are further converted in the same pot to the corresponding α-azidoketones using NaN3/NaHCO3. The one-pot conversions are versatile for a variety of olefins that include cyclic as well as acyclic aliphatic olefins and electron-rich and electron-deficient styrenes. Chemoselective bromohydroxylation of electron-rich double bond and subsequent oxidation to the α-bromoketone is demonstrated for a substrate that contains both electron-rich and deficient double bonds.
Method for preparing organic bromide by using micro-channel reactor
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Paragraph 0071; 0072; 0073; 0074; 0075, (2016/11/28)
The invention discloses a method for preparing an organic bromide by using a micro-channel reactor. The method comprises the step of: performing a bromination reaction on a homogeneous solution formed by a compound shown in a formula I and a solvent and a homogeneous solution formed by a bromination agent and a solvent in the micro-channel reactor to obtain the organic bromide represented by a formula II, wherein the bromination reaction time is 1-10 minutes; the bromination reaction temperature is DEG C to 60 DEG C. The preparation method disclosed by the invention is extremely short, accurate to control reaction condition, high in safety and suitable for quick preparation of products, can be used for continuously production, and is low in cost. Moreover, by using the micro-channel reactor to prepare the organic bromide, the selectivity of reaction raw materials is high and the purity of a targerted compound is good, so that the preparation method is suitable for industrial production on a large scale. R1-H-R1-BrI II.