2-[prop-2-ynyl-(toluene-4-sulfonyl)-amino]-2-trifluoromethyl-but-3-enoic acid methyl ester

Base Information

Chemical Name:2-[prop-2-ynyl-(toluene-4-sulfonyl)-amino]-2-trifluoromethyl-but-3-enoic acid methyl ester
CAS No.:864166-09-6
Molecular Formula:C₁₆H₁₆F₃NO₄S
Molecular Weight:375.369
Hs Code.:

Synonyms:2-[prop-2-ynyl-(toluene-4-sulfonyl)-amino]-2-trifluoromethyl-but-3-enoic acid methyl ester

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Chemical Property of 2-[prop-2-ynyl-(toluene-4-sulfonyl)-amino]-2-trifluoromethyl-but-3-enoic acid methyl ester

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Technology Process of 2-[prop-2-ynyl-(toluene-4-sulfonyl)-amino]-2-trifluoromethyl-but-3-enoic acid methyl ester

There total 3 articles about 2-[prop-2-ynyl-(toluene-4-sulfonyl)-amino]-2-trifluoromethyl-but-3-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1332879-53-4
C₁₃H₁₄F₃NO₄S

: 106-96-7
propargyl bromide

: 864166-09-6
2-[prop-2-ynyl-(toluene-4-sulfonyl)-amino]-2-trifluoromethyl-but-3-enoic acid methyl ester

Guidance literature:: C₁₃H₁₄F₃NO₄S; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

propargyl bromide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201101209

Reference yield:

: 370877-57-9
methyl 3,3,3-trifluoro-2-(tosylimino)propanoate

: 864166-09-6
2-[prop-2-ynyl-(toluene-4-sulfonyl)-amino]-2-trifluoromethyl-but-3-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1002/chem.201101209