Technology Process of ethyl 2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoate
There total 7 articles about ethyl 2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chloro-trimethyl-silane;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 72h;
Inert atmosphere;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: methanol / 192 h / 20 °C
2: potassium hydrogencarbonate / acetonitrile / 27 h / Reflux
3: sodium ethanolate / ethanol / 0.5 h / Inert atmosphere; Reflux
4: chloro-trimethyl-silane / N,N-dimethyl-formamide / 72 h / 100 °C / Inert atmosphere; Sealed tube
With
chloro-trimethyl-silane; sodium ethanolate; potassium hydrogencarbonate;
In
methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 1.5 h / -78 °C
1.2: 4 h / -78 - 20 °C
2.1: boron tribromide / dichloromethane; hexane / 2 h / -78 - 20 °C / Inert atmosphere
3.1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 72 h / 100 °C / Inert atmosphere; Sealed tube
With
N,N,N,N,N,N-hexamethylphosphoric triamide; chloro-trimethyl-silane; boron tribromide; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
