2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoic acid

Base Information

Chemical Name:2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoic acid
CAS No.:1377565-43-9
Molecular Formula:C₂₃H₂₇N₃O₂
Molecular Weight:377.486
Hs Code.:

Synonyms:2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoic acid

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Chemical Property of 2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoic acid

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Technology Process of 2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoic acid

There total 8 articles about 2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 1377567-48-0
ethyl 2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoate

: 1377565-43-9
2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoic acid

Guidance literature:: ethyl 2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoate; With methanol; ethanol; sodium hydroxide; at 60 ℃; for 18h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 5693-62-9
2,3,4,5-tetrahydro-6-methoxypyridine

: 1377565-43-9
2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 192 h / 20 °C

2.1: potassium hydrogencarbonate / acetonitrile / 27 h / Reflux

3.1: sodium ethanolate / ethanol / 0.5 h / Inert atmosphere; Reflux

4.1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 72 h / 100 °C / Inert atmosphere; Sealed tube

5.1: sodium hydroxide; ethanol; methanol / 18 h / 60 °C

5.2: pH 2

With methanol; chloro-trimethyl-silane; ethanol; sodium ethanolate; potassium hydrogencarbonate; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 941-43-5
Ethyl levulinate ethylene ketal

: 1377565-43-9
2-(2-methyl-4-p-tolyl-5,6,7,8-tetrahydropyridino[1,2-b]imidazo[4,5-b]pyridin-3-yl)pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 1.5 h / -78 °C

1.2: 4 h / -78 - 20 °C

2.1: boron tribromide / dichloromethane; hexane / 2 h / -78 - 20 °C / Inert atmosphere

3.1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 72 h / 100 °C / Inert atmosphere; Sealed tube

4.1: sodium hydroxide; ethanol; methanol / 18 h / 60 °C

4.2: pH 2

With methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; chloro-trimethyl-silane; ethanol; boron tribromide; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;