o-Methylvalerolactim

Base Information

• Chemical Name: o-Methylvalerolactim
• CAS No.: 5693-62-9
• Molecular Formula: C6H11NO
• Molecular Weight: 113.159
• Hs Code.: 2933399090
• Mol file: 5693-62-9.mol

Synonyms:1-Aza-2-methoxy-1-cyclohexene;2,3,4,5-Tetrahydro-6-methoxypyridine;2-Methoxy-3,4,5,6-tetrahydropyridine;3,4,5,6-Tetrahydro-2-methoxypyridine;6-Methoxy-2,3,4,5-tetrahydropyridine;o-Methyl-d-valerolactim;o-Methylpentanolactim;Valerolactim, o-methyl-;Pyridine,2,3,4,5-tetrahydro-6-methoxy-;

Chemical Property of o-Methylvalerolactim

Chemical Property:

• Vapor Pressure: 5.64mmHg at 25°C
• Refractive Index: 1.488
• Boiling Point: 147.3 °C at 760 mmHg
• Flash Point: 37.8 °C
• PSA: 21.59000
• Density: 1.02 g/cm³
• LogP: 0.65080
• Storage Temp.: 2-8°C

Purity/Quality:

98%min. ^*data from raw suppliers

6-Methoxy-2,3,4,5-tetrahydropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of o-Methylvalerolactim

There total 9 articles about o-Methylvalerolactim which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

piperidin-2-one (675-20-7) + trimethoxonium tetrafluoroborate (420-37-1) → 2,3,4,5-tetrahydro-6-methoxypyridine (5693-62-9)

Guidance literature:

In dichloromethane; at 20 ℃;

Reference yield: 88.0%

piperidin-2-one (675-20-7) + dimethyl sulfate (77-78-1) → 2,3,4,5-tetrahydro-6-methoxypyridine (5693-62-9)

Guidance literature:

at 55 ℃; for 20h;

DOI:10.1016/S0040-4039(00)02323-6

Reference yield:

piperidin-2-one (675-20-7) + methyl trifluoromethanesulfonate (333-27-7) → 2,3,4,5-tetrahydro-6-methoxypyridine (5693-62-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 18h;

upstream raw materials:

piperidin-2-one

dimethyl sulfate

methanol

cyclopentanone oxime tosylate

Downstream raw materials:

9a-methoxy-2-methyl-7,8,9,9a-tetrahydro-6H-pyrido[2,1-b][1,3]oxazin-4-one

2,3,4,5-tetrahydro-6-pyrrolidinopyridine

8-Acetyl-5-phenyl-2,3,4,6-tetrahydro-1H-[1,6]naphthyridin-7-one

2-Cyano-N-phenyl-2-piperidin-(2E)-ylidene-acetamide

Refernces

• 1、 Jones, Keith,Newton, Roger F.,Yarnold, Christopher J.. "Synthetic studies on the ceveratrum alkaloid skeleton". . p. 4133 - 4140. Retrieved 1996.
• 2、 Wu, Xingxing,Zhou, Liejin,Maiti, Rakesh,Mou, Chengli,Pan, Lutai,Chi, Yonggui Robin. "Sulfinate and Carbene Co-catalyzed Rauhut–Currier Reaction for Enantioselective Access to Azepino[1,2-a]indoles". supporting information. p. 477 - 481. Retrieved 2018/12/14.
• 3、 Schmitt, Sven Marcel,Stefan, Katja,Wiese, Michael. "Pyrrolopyrimidine Derivatives as Novel Inhibitors of Multidrug Resistance-Associated Protein 1 (MRP1, ABCC1)". . p. 3018 - 3033. Retrieved 2016/05/19.