4-(2-keto-1-carbomethoxy-2-phenylethyl)-2-oxo-6-methylenebicyclo<3.1.0>hexane

Base Information

• Chemical Name: 4-(2-keto-1-carbomethoxy-2-phenylethyl)-2-oxo-6-methylenebicyclo<3.1.0>hexane
• CAS No.: 97521-45-4
• Molecular Formula: C₁₈H₁₈O₄
• Molecular Weight: 298.339

Synonyms:4-(2-keto-1-carbomethoxy-2-phenylethyl)-2-oxo-6-methylenebicyclo<3.1.0>hexane

Chemical Property of 4-(2-keto-1-carbomethoxy-2-phenylethyl)-2-oxo-6-methylenebicyclo<3.1.0>hexane

Chemical Property:

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Technology Process of 4-(2-keto-1-carbomethoxy-2-phenylethyl)-2-oxo-6-methylenebicyclo<3.1.0>hexane

There total 1 articles about 4-(2-keto-1-carbomethoxy-2-phenylethyl)-2-oxo-6-methylenebicyclo<3.1.0>hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methylenebicyclo<3.1.0>hex-3-ene-2-one (71946-85-5) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → 4-(2-keto-1-carbomethoxy-2-phenylethyl)-2-oxo-6-methylenebicyclo<3.1.0>hexane (97521-45-4)

Guidance literature:

sodium methylate; In methanol; 1.) 15 min, RT; 2.) 6 h;

DOI:10.1021/ja00305a015

Reference yield:

4-(2-keto-1-carbomethoxy-2-phenylethyl)-2-oxo-6-methylenebicyclo<3.1.0>hexane (97521-45-4) → 4-(2-oxo-2-phenylethyl)-2,6-dimethylenebicyclo<3.1.0>hexane (89032-34-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.5 M CH₃Li / tetrahydrofuran / Ambient temperature

2: 21 percent / KOH / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With potassium hydroxide; methyllithium; In tetrahydrofuran; water;

DOI:10.1021/ja00305a015

Reference yield:

Methyltriphenylphosphonium bromide (1779-49-3) + 4-(2-keto-1-carbomethoxy-2-phenylethyl)-2-oxo-6-methylenebicyclo<3.1.0>hexane (97521-45-4) → 4-(2-keto-1-carbomethoxy-2-phenylethyl)-2,6-dimethylenebicyclo<3.1.0>hexane

Guidance literature:

With methyllithium; In tetrahydrofuran; Yield given; Ambient temperature;

DOI:10.1021/ja00305a015

upstream raw materials:

6-methylenebicyclo<3.1.0>hex-3-ene-2-one

ethyl 3-oxo-3-phenylpropionate

Downstream raw materials:

4-(2-oxo-2-phenylethyl)-2,6-dimethylenebicyclo<3.1.0>hexane

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