N-benzyl-1-[(4-methylphenyl)sulfonyl]-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide

Base Information

Chemical Name:N-benzyl-1-[(4-methylphenyl)sulfonyl]-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide
CAS No.:1240791-71-2
Molecular Formula:C₂₄H₂₆N₂O₄S
Molecular Weight:438.547
Hs Code.:

Synonyms:N-benzyl-1-[(4-methylphenyl)sulfonyl]-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide

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Chemical Property of N-benzyl-1-[(4-methylphenyl)sulfonyl]-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide

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Technology Process of N-benzyl-1-[(4-methylphenyl)sulfonyl]-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide

There total 1 articles about N-benzyl-1-[(4-methylphenyl)sulfonyl]-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1240792-17-9
C₁₂H₁₅N

: 1-[(4-methylphenyl)sulfonyl]-2-oxopyrrolidine-3-carboxylate

: 1240791-71-2
N-benzyl-1-[(4-methylphenyl)sulfonyl]-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide

Guidance literature:: In toluene; Reflux;
DOI:10.1021/ol101425y

Reference yield: 68.0%

: 1240791-71-2
N-benzyl-1-[(4-methylphenyl)sulfonyl]-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide

: 619-44-3
methyl 4-iodobenzoate

: (5R,10S)-methyl 4-(1-{7-benzyl-2-[(4-methylphenyl)sulfonyl]-1,6-dioxo-2,7-diazaspiro[4.5]dec-10-yl}vinyl)benzoate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; 1,2-bis-(diphenylphosphino)ethane; In dimethyl sulfoxide; at 70 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/ol101425y

Reference yield:

: 22445-41-6
3,5-dimethylphenyl iodide

: 1240791-71-2
N-benzyl-1-[(4-methylphenyl)sulfonyl]-2-oxo-N-(penta-3,4-dien-1-yl)pyrrolidine-3-carboxamide

: (5SR,10SR)-7-benzyl-10-[1-(3,5-dimethylphenyl)vinyl]-2-[(4-methylphenyl)sulfonyl]-2,7-diazaspiro[4.5]decane-1,6-dione

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; diastereoselective reaction; Sealed tube;
DOI:10.1039/c3cc42079e