2-(4-(ethylsulfonyl)phenyl)-N-(1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-yl)acetamide

Base Information

Chemical Name:2-(4-(ethylsulfonyl)phenyl)-N-(1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-yl)acetamide
CAS No.:1508310-52-8
Molecular Formula:C₂₇H₂₅F₃N₂O₃S
Molecular Weight:514.568
Hs Code.:

Synonyms:2-(4-(ethylsulfonyl)phenyl)-N-(1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-yl)acetamide

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Chemical Property of 2-(4-(ethylsulfonyl)phenyl)-N-(1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-yl)acetamide

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Technology Process of 2-(4-(ethylsulfonyl)phenyl)-N-(1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-yl)acetamide

There total 4 articles about 2-(4-(ethylsulfonyl)phenyl)-N-(1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 1508310-77-7
1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-amine

: 1508310-52-8
2-(4-(ethylsulfonyl)phenyl)-N-(1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-yl)acetamide

Guidance literature:: 2-[4-(ethanesulfonyl)phenyl]acetic acid; 1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-amine; With HATU; In dichloromethane; at 20 ℃; for 0.166667h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ml4003875

Reference yield:

: 1997-80-4
2-(3-trifluoromethylphenyl)-ethyl bromide

: 1508310-52-8
2-(4-(ethylsulfonyl)phenyl)-N-(1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium iodide; caesium carbonate / N,N-dimethyl-formamide / 120 h / 90 °C

2.1: tin(II) chloride dihdyrate; ethanol / 28 h / Reflux

3.1: HATU / dichloromethane / 0.17 h / 20 °C

3.2: 3 h / 20 °C

With tin(II) chloride dihdyrate; ethanol; caesium carbonate; HATU; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml4003875

Reference yield:

: 1508310-76-6
5-nitro-1-(3-(trifluoromethyl)phenethyl)-1H-indole

: 1508310-52-8
2-(4-(ethylsulfonyl)phenyl)-N-(1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tin(II) chloride dihdyrate; ethanol / 28 h / Reflux

2.1: HATU / dichloromethane / 0.17 h / 20 °C

2.2: 3 h / 20 °C

With tin(II) chloride dihdyrate; ethanol; HATU; In dichloromethane;
DOI:10.1021/ml4003875