1997-80-4

Usage

Uses

Used in Pharmaceutical Synthesis:
-METHYL-2-TRIFLUOROMETHYLBENZYL BROMIDE is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its reactivity allows for the introduction of the benzyl group into target molecules, enhancing the pharmacological properties of the resulting compounds.
Used in Agrochemical Production:
In the agrochemical industry, -METHYL-2-TRIFLUOROMETHYLBENZYL BROMIDE serves as an intermediate in the synthesis of agrochemicals, including pesticides and herbicides. Its role in these processes helps to create effective and targeted agricultural products.
Used in Organic Compounds Synthesis:
-METHYL-2-TRIFLUOROMETHYLBENZYL BROMIDE is utilized as a building block for the synthesis of complex organic molecules, which may have potential applications in materials chemistry and other fields. Its ability to facilitate the creation of intricate molecular structures makes it a valuable component in organic chemistry.
Used in Medicinal Chemistry Research:
As a highly reactive compound, -METHYL-2-TRIFLUOROMETHYLBENZYL BROMIDE is employed in medicinal chemistry research to explore its potential applications in the development of new therapeutic agents and the enhancement of existing ones. Its unique properties and reactivity offer opportunities for innovation in drug discovery and design.

Upstream product

• 455-01-6 2-[3-(trifluoromethyl)phenyl]ethanol 
• 351-35-9 3-(trifluoromethyl)phenylacetic acid 
• 705-29-3 3-Trifluoromethylbenzyl chloride 
• 2338-76-3 3-trifluoromethylphenylacetonitrile 
• 62451-84-7 (3-trifluoromethyl-phenyl)-acetic acid methyl ester 

Downstream Products

• 25017-13-4 1-(2-bromoethyl)-3-fluorobenzene 
• 129254-85-9 1-(3-trifluoromethylphenyl)-3-(pyridin-4-yl)-butane 
• 147520-36-3 3-[(N-(2-(3-Trifluoromethylphenyl)-ethyl)-piperidin-3-yl)methyl]-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one-hydrochloride 
• 823189-10-2 3-(trifluoromethyl)phenethyl azide 
• 1613028-93-5 2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(3-(trifluoromethyl)phenethyl)-benzenesulfonamide 
• 52516-30-0 2-(3-trifluoromethylphenyl)ethylamine 
• 1508310-76-6 5-nitro-1-(3-(trifluoromethyl)phenethyl)-1H-indole 
• 1508310-52-8 2-(4-(ethylsulfonyl)phenyl)-N-(1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-yl)acetamide 
• 1508310-77-7 1-(3-(trifluoromethyl)phenethyl)-1H-indol-5-amine 
• 1382354-23-5 2-{3-(3-trifluoromethylphenethoxy)phenylamino}benzamide 

Relevant academic research and scientific papers

PYRROLOPYRIMIDINE DERIVATIVES USEFUL AS MODULATORS OF MULTIDRUG RESISTANCE

A compound which is a pyrrolopyrimidine of formula (I) wherein: R1 is selected from R9 and halogen; R2 is NR6R7; R3 is selected from H, C1-C6 alkyl which is unsubstituted or substituted and -(CH2) nAr; R4 is selected from H, C1-C6 alkyl and -(CH2)? Ar; or R3 and R4 form, together with the N and C atoms to which they are attached, a fused five-, six-, seven- or eight-membered N-containing saturated ring which is unsubstituted or substituted; R5 is selected from CN, C02R9,C(O)NR10R11, -(CH2)nOH, -(CH2)nR10Rn, -C=CH, -C(S)NR10R11, -C(NH2)=NOR9, -C(R9)=NOR9, -C(NH2)NH, -C(O)R9 and an unsaturated 5- or 6-membered heterocyclic group which contains 1, 2 or 3 heteroatoms selected from N, O and S and which is unsubstituted or substituted; R6 and R7, which are the same or different, are selected from C1-C6 alkyl which is unsubstituted or substituted, -(CH2)nX and -(CH2)nAr; or R6 and R7 form, together with the nitrogen atom to which they are attached, a saturated five-, six-, seven- or eight-membered heterocyclic group which contains one nitrogen atom and 0 or from 1 to 3 additional heteroatoms selected from N, O and S, which is unsubstituted or substituted and which optionally contains one or two bridgehead atoms; R10and R11,which are the same or different, are selected from H, C1-C6 alkyl which is unsubstituted or substituted, -(CH2)nC3-C10 cycloalkyl and -(CH2)nAr; or R10 and R11 form, together with the nitrogen atom to which they are attached, a saturated five or six membered heterocyclic group which contains a nitrogen atom and 0 or from to 3 additional heteroatoms selected from O, S and N, which is unsubstituted or substituted and which is optionally fused to a benzene ring which is unsubstituted or substituted; n is the same or different when more than one is present within a given substituent group and is 0 or an integer of from 1 to 6; X is selected from -CN, -C02R9 and -NR10R11; R9 is the same or different when more than one is present within a given substituent group and is selected from -H, -QAr, -(CH2) nAr, C1-C6 alkyl which is unsubstituted or substituted and -(CH2) nC3-C10cycloalkyl, wherein the cycloalkyl moiety is optionally fused to a benzene ring which is unsubstituted or substituted; Q is C2-C6 alkenylene or alkynylene; and Ar is an unsaturated C6-C10 membered carbocyclic group or an unsaturated 5-11 membered heterocyclic group, which groups are unsubstituted or substituted; or a pharmaceutically acceptable salt thereof. These compounds have activity as inhibitors of MRP (multidrug resistant protein) and may thus be used to modulate multidrug resistance, for instance in potentiating the cytotoxicity of a chemotherapeutic agent.

New prenylamine-analogues: investigations of their influence on calcium-dependent biological systems

Chemically, prenylamine belongs to the diphenylalkylamine class.Compounds of this class are calcium antagonists with broad spectrum of activities due to their influence on both extracellular and intracellular sites.In the present study the calcium antagonistic profile of a recently developed new series of prenylamine analogues has been investigated using different in vitro systems.The inhibiting concentrations for the most active compound are ca. 1.5 μM; several derivatives are inactive up to a concentration of 10 μM.Structural modifications towards an increase oflipophilicity make these molecules interact (inhibition) with the intracellular calcium-binding protein calmodulin; for the series no correlation between calcium-blocking and calmodulin antagonistic effects has been found. - Keywords: prenylamine derivatives /diphenylalkylamines /calcium antagonists / calmodulin antagonists / qualitative structure-activity relationship