3-[1-(4-Methoxy-phenyl)-7-trifluoromethyl-1H-imidazo[4,5-c]quinolin-4-ylamino]-propan-1-ol

Base Information

Chemical Name:3-[1-(4-Methoxy-phenyl)-7-trifluoromethyl-1H-imidazo[4,5-c]quinolin-4-ylamino]-propan-1-ol
CAS No.:1060673-50-8
Molecular Formula:C₂₁H₁₉F₃N₄O₂
Molecular Weight:416.403
Hs Code.:

Synonyms:3-[1-(4-Methoxy-phenyl)-7-trifluoromethyl-1H-imidazo[4,5-c]quinolin-4-ylamino]-propan-1-ol

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Chemical Property of 3-[1-(4-Methoxy-phenyl)-7-trifluoromethyl-1H-imidazo[4,5-c]quinolin-4-ylamino]-propan-1-ol

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Technology Process of 3-[1-(4-Methoxy-phenyl)-7-trifluoromethyl-1H-imidazo[4,5-c]quinolin-4-ylamino]-propan-1-ol

There total 6 articles about 3-[1-(4-Methoxy-phenyl)-7-trifluoromethyl-1H-imidazo[4,5-c]quinolin-4-ylamino]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1060674-20-5
4-chloro-1-(4-methoxyphenyl)-7-(trifluoromethyl)-1 H-imidazo[4,5-c]quinoline

: 156-87-6
propan-1-ol-3-amine

: 1060673-50-8
3-[1-(4-Methoxy-phenyl)-7-trifluoromethyl-1H-imidazo[4,5-c]quinolin-4-ylamino]-propan-1-ol

Guidance literature:: In 1,4-dioxane; for 23h; Heating / reflux;

Reference yield:

: 869550-69-6
7-(trifluoromethyl)-4-hydroxyquinolin-2(1H)-one

: 1060673-50-8
3-[1-(4-Methoxy-phenyl)-7-trifluoromethyl-1H-imidazo[4,5-c]quinolin-4-ylamino]-propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid; acetic acid / water / 1 h / 0 - 100 °C

1.2: pH 9

2.1: P,P-dichlorophenylphosphine oxide / 17 h / 140 °C

2.2: 0.17 h / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: sodium tetrahydroborate; nickel dichloride / tetrahydrofuran; methanol / 0.33 h / 0 - 20 °C

5.1: toluene-4-sulfonic acid / toluene / 3 h / Heating / reflux

6.1: 1,4-dioxane / 23 h / Heating / reflux

With P,P-dichlorophenylphosphine oxide; sodium tetrahydroborate; nitric acid; toluene-4-sulfonic acid; acetic acid; triethylamine; nickel dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 869550-70-9
7-(trifluoromethyl)-4-hydroxy-3-nitroquinolin-2(1H)-one

: 1060673-50-8
3-[1-(4-Methoxy-phenyl)-7-trifluoromethyl-1H-imidazo[4,5-c]quinolin-4-ylamino]-propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: P,P-dichlorophenylphosphine oxide / 17 h / 140 °C

1.2: 0.17 h / 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: sodium tetrahydroborate; nickel dichloride / tetrahydrofuran; methanol / 0.33 h / 0 - 20 °C

4.1: toluene-4-sulfonic acid / toluene / 3 h / Heating / reflux

5.1: 1,4-dioxane / 23 h / Heating / reflux

With P,P-dichlorophenylphosphine oxide; sodium tetrahydroborate; toluene-4-sulfonic acid; triethylamine; nickel dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;