tert-butyl 2-(2-(1,3-dioxolan-2-yl)phenyl)-2-cyanopropanoate

Base Information

Chemical Name:tert-butyl 2-(2-(1,3-dioxolan-2-yl)phenyl)-2-cyanopropanoate
CAS No.:1491842-34-2
Molecular Formula:C₁₇H₂₁NO₄
Molecular Weight:303.358
Hs Code.:

Synonyms:tert-butyl 2-(2-(1,3-dioxolan-2-yl)phenyl)-2-cyanopropanoate

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Chemical Property of tert-butyl 2-(2-(1,3-dioxolan-2-yl)phenyl)-2-cyanopropanoate

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Technology Process of tert-butyl 2-(2-(1,3-dioxolan-2-yl)phenyl)-2-cyanopropanoate

There total 4 articles about tert-butyl 2-(2-(1,3-dioxolan-2-yl)phenyl)-2-cyanopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 34824-58-3
2-(2-bromophenyl)-1,3-dioxolan

: 1116-98-9
cyanoacetic acid tert-butyl ester

: 74-88-4
methyl iodide

: 1491842-34-2
tert-butyl 2-(2-(1,3-dioxolan-2-yl)phenyl)-2-cyanopropanoate

Guidance literature:: 2-(2-bromophenyl)-1,3-dioxolan; cyanoacetic acid tert-butyl ester; With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium t-butanolate; In 1,4-dioxane; at 70 ℃; for 4h;

methyl iodide; at 70 ℃; for 8h;
DOI:10.1039/c5ob02320c

Reference yield:

: tert-butyl 2-(2-(1,3-dioxolan-2-yl)phenyl)-2-cyanoacetate

: 74-88-4
methyl iodide

: 1491842-34-2
tert-butyl 2-(2-(1,3-dioxolan-2-yl)phenyl)-2-cyanopropanoate

Guidance literature:: With sodium t-butanolate; In 1,4-dioxane; at 70 ℃; for 8h; Inert atmosphere;
DOI:10.1021/ol4030309

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1491842-34-2
tert-butyl 2-(2-(1,3-dioxolan-2-yl)phenyl)-2-cyanopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene / 18 h / Dean-Stark; Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium t-butanolate / 1,4-dioxane / 4 h / 70 °C / Inert atmosphere

3: sodium t-butanolate / 1,4-dioxane / 8 h / 70 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; toluene-4-sulfonic acid; sodium t-butanolate; In 1,4-dioxane; toluene;
DOI:10.1021/ol4030309