(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate

Base Information

Chemical Name:(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate
CAS No.:1419222-20-0
Molecular Formula:C₂₇H₃₉NO₅Si
Molecular Weight:485.696
Hs Code.:

Synonyms:(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate

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Chemical Property of (2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate

Chemical Property:

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Technology Process of (2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate

There total 4 articles about (2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1419222-19-7
((2R,5R)-4-benzyl-5-(((tert-butyldiphenylsilyl)oxy)methyl)morpholin-2-yl) methanol

: 1419222-20-0
(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate

Guidance literature:: With hydrogen; palladium(II) hydroxide; triethylamine; In ethanol; at 20 ℃; for 20h; under 2327.23 - 2585.81 Torr; Inert atmosphere;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1419222-20-0
(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C

2: methanol; lithium borohydride / tetrahydrofuran / 16 h / 20 °C

3: lithium perchlorate; sodium methylate / toluene / 120 h / 20 °C

4: triethylamine; palladium(II) hydroxide; hydrogen / ethanol / 20 h / 20 °C / 2327.23 - 2585.81 Torr / Inert atmosphere

With methanol; dmap; lithium borohydride; hydrogen; sodium methylate; lithium perchlorate; palladium(II) hydroxide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1419222-18-6
(R)-2-(benzylamino)-3-((tert-butyldiphenylsilyl)oxy)propan-1-ol

: 1419222-20-0
(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium perchlorate; sodium methylate / toluene / 120 h / 20 °C

2: triethylamine; palladium(II) hydroxide; hydrogen / ethanol / 20 h / 20 °C / 2327.23 - 2585.81 Torr / Inert atmosphere

With hydrogen; sodium methylate; lithium perchlorate; palladium(II) hydroxide; triethylamine; In ethanol; toluene;