(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(8-chloro imidazo[1,5-a]pyrazin-3-yl)morpholine-4-carboxylate

Base Information

Chemical Name:(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(8-chloro imidazo[1,5-a]pyrazin-3-yl)morpholine-4-carboxylate
CAS No.:1620676-27-8
Molecular Formula:C₃₂H₃₉ClN₄O₄Si
Molecular Weight:607.225
Hs Code.:

Synonyms:(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(8-chloro imidazo[1,5-a]pyrazin-3-yl)morpholine-4-carboxylate

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Chemical Property of (2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(8-chloro imidazo[1,5-a]pyrazin-3-yl)morpholine-4-carboxylate

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Technology Process of (2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(8-chloro imidazo[1,5-a]pyrazin-3-yl)morpholine-4-carboxylate

There total 8 articles about (2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(8-chloro imidazo[1,5-a]pyrazin-3-yl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1620676-25-6
(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(((3-chloropyrazin-2-yl)methyl)carbamoyl)morpholine-4-carboxylate

: 1620676-27-8
(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(8-chloro imidazo[1,5-a]pyrazin-3-yl)morpholine-4-carboxylate

Guidance literature:: With trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile; at 0 - 40 ℃; for 0.75h; Inert atmosphere;

Reference yield: 49.0%

: (2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(((3-chloropyrazin-2-yl)methyl)carbamoyl)morpholine-4-carboxylate

: 1620676-27-8
(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(8-chloro imidazo[1,5-a]pyrazin-3-yl)morpholine-4-carboxylate

Guidance literature:: With trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile; at 0 - 40 ℃; for 0.75h; Inert atmosphere;

Reference yield:

: 1419222-20-0
(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate

: 1620676-27-8
(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(8-chloro imidazo[1,5-a]pyrazin-3-yl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 0 - 20 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Inert atmosphere

3: trichlorophosphate / acetonitrile; N,N-dimethyl-formamide / 0.75 h / 0 - 40 °C / Inert atmosphere

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; triethylamine; HATU; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;