(2R,5R)-4-(tert-butoxycarbonyl)-5-(((tert-butyl diphenylsilyl)oxy)methyl)morpholine-2-carboxylic acid

Base Information

Chemical Name:(2R,5R)-4-(tert-butoxycarbonyl)-5-(((tert-butyl diphenylsilyl)oxy)methyl)morpholine-2-carboxylic acid
CAS No.:1620676-26-7
Molecular Formula:C₂₇H₃₇NO₆Si
Molecular Weight:499.679
Hs Code.:

Synonyms:(2R,5R)-4-(tert-butoxycarbonyl)-5-(((tert-butyl diphenylsilyl)oxy)methyl)morpholine-2-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5R)-4-(tert-butoxycarbonyl)-5-(((tert-butyl diphenylsilyl)oxy)methyl)morpholine-2-carboxylic acid

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Technology Process of (2R,5R)-4-(tert-butoxycarbonyl)-5-(((tert-butyl diphenylsilyl)oxy)methyl)morpholine-2-carboxylic acid

There total 5 articles about (2R,5R)-4-(tert-butoxycarbonyl)-5-(((tert-butyl diphenylsilyl)oxy)methyl)morpholine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1419222-20-0
(2R,5R)-tert-butyl 5-(((tert-butyldiphenylsilyl)oxy)methyl)-2-(hydroxymethyl) morpholine-4-carboxylate

: 1620676-26-7
(2R,5R)-4-(tert-butoxycarbonyl)-5-(((tert-butyl diphenylsilyl)oxy)methyl)morpholine-2-carboxylic acid

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1620676-26-7
(2R,5R)-4-(tert-butoxycarbonyl)-5-(((tert-butyl diphenylsilyl)oxy)methyl)morpholine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; triethylamine / dichloromethane / 0 - 20 °C

2: methanol; lithium borohydride / tetrahydrofuran / 16 h / 20 °C

3: lithium perchlorate; sodium methylate / toluene / 120 h / 20 °C

4: triethylamine; palladium(II) hydroxide; hydrogen / ethanol / 20 h / 20 °C / 2327.23 - 2585.81 Torr / Inert atmosphere

5: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 0 - 20 °C

With methanol; dmap; lithium borohydride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; hydrogen; sodium methylate; lithium perchlorate; palladium(II) hydroxide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1419222-19-7
((2R,5R)-4-benzyl-5-(((tert-butyldiphenylsilyl)oxy)methyl)morpholin-2-yl) methanol

: 1620676-26-7
(2R,5R)-4-(tert-butoxycarbonyl)-5-(((tert-butyl diphenylsilyl)oxy)methyl)morpholine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; palladium(II) hydroxide; hydrogen / ethanol / 20 h / 20 °C / 2327.23 - 2585.81 Torr / Inert atmosphere

2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 0 - 20 °C

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; hydrogen; palladium(II) hydroxide; triethylamine; In ethanol; dichloromethane;