4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol

Base Information

Chemical Name:4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol
CAS No.:1354819-29-6
Molecular Formula:C₁₄H₁₄FN₃O₄
Molecular Weight:307.281
Hs Code.:

Synonyms:4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol

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Chemical Property of 4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol

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Technology Process of 4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol

There total 1 articles about 4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 259209-20-6
5-fluoro-2-hydroxyphenyl-boronic acid

: 89717-64-6
4-bromo-3-nitro-1H-pyrazole

: 1354819-29-6
4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol

Guidance literature:: 3,4-dihydro-2H-pyran; 4-bromo-3-nitro-1H-pyrazole; With trifluoroacetic acid; In toluene; at 80 ℃; for 23h;

5-fluoro-2-hydroxyphenyl-boronic acid; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1354819-29-6
4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol

: 1354819-13-8
C₂₈H₂₈ClF₂N₅O₆S₂

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 24 h / 20 °C

2: ammonium chloride; iron / ethanol; water / 4 h / 80 °C

With iron; potassium carbonate; ammonium chloride; In ethanol; water; dimethyl sulfoxide;

Reference yield:

: 1354819-29-6
4-fluoro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol

: 1354818-92-0
4-[2-(5-amino-1H-pyrazol-4-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 24 h / 20 °C

2: ammonium chloride; iron / ethanol; water / 4 h / 80 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 50 °C

With hydrogenchloride; iron; potassium carbonate; ammonium chloride; In 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide;